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allosteric
(redirected from allosterically)

   Also found in: Dictionary/thesaurus, Wikipedia 0.01 sec.
allosteric /al·lo·ster·ic/ (al″o-ster´ik) pertaining to allostery.
allosteric [al″o-ster´ik]
pertaining to an effect produced on the biological function of a protein by a compound not directly involved in that function (an allosteric effector) or to regulation of an enzyme involving cooperativity between multiple binding sites (allosteric sites).
allosteric site that subunit of an enzyme molecule which binds with a nonsubstrate molecule, inducing a change in form or shape that results in inactivation of the enzyme for its substrate.

allosteric
pertaining to an effect on the biological function of a protein, produced by a compound not directly involved in that function (an allosteric effector) or to regulation of an enzyme involving cooperativity between multiple binding sites (allosteric sites).

allosteric enzymes
any enzymes containing an allosteric site, where effector molecules can bind to increase or decrease the rate of reaction, in addition to an active site for substrate binding. Allosteric enzymes exhibit sigmoidal rather than Michaelis-Menten kinetics.
allosteric site
that site on an enzyme molecule which binds with a nonsubstrate molecule, inducing a conformational change that results in an alteration of the affinity of the enzyme for its substrate.


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Recently it was shown that the binding effectiveness of ATP analogue [beta], [gamma]-imidoadenosine 5'-triphosphate (AMPPNP) and peptide substrate LRRASLG (kemptide) with protein kinase A is effectively controlled allosterically [13].
It is a reversible competitive AChE inhibitor that also allosterically modulates nicotinic receptors (this effect is probably independent of its cholinesterase inhibition).
Ligand binding to the peripheral site can block access of substrates or allosterically alter the catalytic efficiency of AChE, but more importantly for our considerations, it interferes with its nonenzymatic adhesion functions that are required for axonogenesis and other developmental events (Bourne et al.
 
 
 
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