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allosteric site |
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? Mentioned in | ? References in periodicals archive | |
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This model suggested that SULT1E1 could bind
two molecules of estradiol per molecule of enzyme, one at a preferred
site for sulfonation and the other at an allosteric site associated with
substrate inhibition (Zhang et al. In its lead inflammation program, Locus has created exquisitely
selective p38 inhibitors which bind to p38 at an allosteric site and do
not involve the ATP site. Allosteric sites may offer an improved
safety profile over ATP site inhibitors as well as provide a dual mode
of action. |
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