allosteric inhibitors

allosteric inhibitors

substances which prevent an enzyme from changing into an active form by combining not with the ACTIVE SITE but with some other part of the enzyme.
References in periodicals archive ?
sup][17] Up-to-date, lots of IKK[sz] inhibitors have been developed including ATP analogs (PS-1145 and ML120B), allosteric inhibitors (BMS-345541), and thiol-reactive compounds (parthenolide and arsenite).
to cover many current and relevant aspects of protein-protein interactions, overcoming resistance in drug design, and allosteric inhibitors.
Instead, this new class, called allosteric inhibitors, changes the shape of the target enzyme and in doing so, renders it inactive.
The reversible Hill equation is widely used to model the kinetics of biochemical reaction networks with allosteric inhibitors and/or activators.
Understanding the issues that govern HIV-PR flap mobility has profound implications for elucidating the detailed mechanism of this enzyme and in the design of new therapeutic agents, such as allosteric inhibitors intended to interfere with flap opening and, thereby, with protease function.