allosteric


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Related to allosteric: allosteric site

allosteric

 [al″o-ster´ik]
pertaining to an effect produced on the biological function of a protein by a compound not directly involved in that function (an allosteric effector) or to regulation of an enzyme involving cooperativity between multiple binding sites (allosteric sites).
allosteric site that subunit of an enzyme molecule which binds with a nonsubstrate molecule, inducing a change in form or shape that results in inactivation of the enzyme for its substrate.

al·lo·ste·ric

(al'ō-ster'ik),
Pertaining to or characterized by allosterism.

allosteric

/al·lo·ster·ic/ (al″o-ster´ik) pertaining to allostery.

allosteric

(ăl′ə-stĕr′ĭk)
adj.
Of or relating to the binding of a molecule to an enzyme at a site other than the active site, resulting in modulation of the enzyme's activity as a result of a change in its shape.

al′lo·ster′i·cal·ly adv.
al·los′ter·y (ə-lŏs′tə-rē) n.

allosteric

Biochemistry
adjective
(1) Referring to allostery, see there.
(2) Referring to the alteration of a binding site on a protein, usually an enzyme, due to interaction with another molecule.
 
Molecular biology
adjective Referring to the stereospecific modification of a protein by an effector to influence other protein- or nucleic acid-binding site activity.

al·lo·ste·ric

(al'ō-ster'ik)
Pertaining to or characterized by allosterism.

allosteric

pertaining to an effect on the biological function of a protein, produced by a compound not directly involved in that function (an allosteric effector) or to regulation of an enzyme involving cooperativity between multiple binding sites (allosteric sites).

allosteric enzymes
any enzymes containing an allosteric site, where effector molecules can bind to increase or decrease the rate of reaction, in addition to an active site for substrate binding. Allosteric enzymes exhibit sigmoidal rather than Michaelis-Menten kinetics.
allosteric site
that site on an enzyme molecule which binds with a nonsubstrate molecule, inducing a conformational change that results in an alteration of the affinity of the enzyme for its substrate.
References in periodicals archive ?
Molecular blueprint of novel allosteric binding sites in the agonist-binding domain of the ui7 nicotinic acetylcholine receptor, PNAS, 2015, 112(19):E2543-E2552 (DOI:10.
The paper describes the identification and characterization of a pepducin-based allosteric agonist that targets CXCR4, a chemokine G protein-coupled receptor (GPCR) found on hematopoietic stem cells and other bone marrow-derived cells.
With its small molecule library, CompleGen has identified potent allosteric inhibitors for targets where other discovery platforms have failed.
OXY111A is one of a new class of allosteric effectors of hemoglobin, called oxyrens (oxygen release enhancers).
Allosterix is developing novel platform technology for the design of allosteric drug-able enzyme inhibitors.
Pre-clinical work from Biodesy to develop allosteric and conformation-specific drugs targeting alpha-synuclein
While the treatment of CNS diseases has long been viewed as a challenging and largely underserved space in drug development, SAGE Therapeutics' proprietary Positive and Negative Allosteric Modulator (PANAM) chemistry platform combined with Ligand's Captisol technology may enable the rapid development of allosteric receptor modulators that target these critical pathways to fine tune and balance the neuronal activity that is disrupted in CNS disorders.
We believe that alpha7 modulators have the potential to become significant therapeutic agents, and we believe that the portfolio of allosteric modulators and the expertise that Anvyl brings provides a unique 2nd generation approach to the established alpha 7 agonist program that CoMentis has advanced.
Pepducins are lipidated peptides designed to be allosteric modulators for G protein coupled receptor (GPCR) targets, especially those intractable to current approaches.
SAGE Therapeutics is founded on a proprietary Positive and Negative Allosteric Modulator (PANAM) chemistry platform that will enable the rapid development of a novel class of allosteric receptor modulators.
Among the examples are: the protection/stabilization of intermediates and transport of the encapsulated materials after pore closing, systematic studies regarding the generation of hydrophobic cavities with and without water (of importance for protein research and even related to drug design), the removal of a variety of hydrophobic (potentially toxic) compounds from water based on molecular recognition (a paradigmatic shift) and finally, stepwise capsule closing and opening related to allosteric effects.