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allosteric |
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allosteric /al·lo·ster·ic/ (al?o-ster´ik) pertaining to allostery. allosteric pertaining to an effect on the biological function of a protein, produced by a compound not directly involved in that function (an allosteric effector) or to regulation of an enzyme involving cooperativity between multiple binding sites (allosteric sites). allosteric enzymes any enzymes containing an allosteric site, where effector molecules can bind to increase or decrease the rate of reaction, in addition to an active site for substrate binding. Allosteric enzymes exhibit sigmoidal rather than Michaelis-Menten kinetics. allosteric site that site on an enzyme molecule which binds with a nonsubstrate molecule, inducing a conformational change that results in an alteration of the affinity of the enzyme for its substrate. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Vivalis know-how and proprietary technology are focused in three main
areas: licensing the proprietary ebx(TM) chicken embryonic stem cell
lines to the pharma and biotech industry, in particular for vaccine and
proteins production; contract manufacturing of pre-clinical and clinical
batches of viral vaccines and recombinant proteins; and discovery of new
anti-viral allosteric modulators through its proprietary
3D-Screen(TM)[3] platform. The
oxygen binding affinity of natural human hemoglobin is too high when it
is free in the blood stream (not contained within erythrocytes) because
of a lack of allosteric control. In its lead inflammation program, Locus has created exquisitely
selective p38 inhibitors which bind to p38 at an allosteric site and do
not involve the ATP site. |
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allosteric
