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allostatic load

   Also found in: Encyclopedia, Wikipedia 0.02 sec.
allostatic load,
a term coined as a more precise alternative to the term stress, used to refer to environmental challenges that cause an organism to begin efforts to maintain stability (allostasis).


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Laboratory research on allostatic load, the body's response to chronically stressful life conditions, has established that these physiologic responses experienced over time can lead to altered functioning of the hypothalamic-pituitary-adrenal axis and to increased risk of CVD (Bjorntorp 2001; Esch et al.
Allostasis, allostatic load, and the aging nervous system: role of excitatory amino acids and excitotoxicity.
Chronic activation of the stress system is believed to lead to allostatic load, which is the "wear and tear" on organ systems resulting from stress (McEwen 1998).
 
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