As the experience of the centers increase and the mechanisms of immune alloreactivity
are elucidated, authors believe that the success in this field will be enhanced.
Another important distinction is that newborn stem cells exhibit reduced alloreactivity
and require less stringent human lymphocyte antigen (HLA) matching in traditional transplant applications than adult stem cells derived from other sources such as bone marrow.
Complement C4d in graft capillaries--the missing link in the recognition of humoral alloreactivity
It is therefore crucial to develop tools that enable monitoring of T-cell alloreactivity
According to the company, the panel of reactive T cells (PRT) test assesses a solid organ transplant candidate's T cell response to foreign tissue, referred to as alloreactivity
, the body's reaction to foreign tissue.
The TALEN -based gene editing (knock-out of the TCR-alpha and CD52 genes) is designed to suppress T-cell alloreactivity
and confer resistance to alemtuzumab to the T-cells.
Natural killer cell alloreactivity
in allogeneic hematopoietic transplantation.
Increased prevalence of autoimmune phenomena and greater risk for alloreactivity
in female heart transplant recipients.
lymphocyte proliferation [proliferating cell nuclear antigen (PCNA) measurement], expression of specific T- and B-cell surface antigens, and intracellular markers (such as cytokine expression, cytokine mRNA expression, and drug concentration); (c) measure soluble cytokines; (d) measure interferon-[gamma] (IFN-[gamma]) alloreactivity
[enzyme-linked immunosorbent spot (ELISPOT)]; and (e) balance T-effector cells/ T-regulatory cells (Tregs) (alloreactivity
6,16,17] Their combined effects result in an increased immune response and increased organ alloreactivity
This work gathers the latest research in the field of transplantation immunology, in areas such as T-cell immunity, antigen presentation, alloreactivity
, pancreas and islet cell transplantation, allogenic bone marrow transplantation, models of tolerance induction, xenotransplantation, and the swine leukocyte complex.
The company said the panel of reactive T cells (PRT) test assesses a solid organ transplant candidate's T cell response to foreign tissue, referred to as alloreactivity