The first involves studies of single and multi-cellular algae which serves as model systems for allometric scaling
laws in evolution.
EPA and its stakeholders be spending so much effort refining allometric scaling
procedures, dialing back the estimation of exposure to the maximally exposed individual, and positing sophisticated nonl inear modes of action, while continuing to make the unscientific assertion that we are all equally susceptible to carcinogenesis?
In contrast, the pharmacokinetic behavior observed in mallards appears to follow the principles of allometric scaling
Models of growth rates of early life stages of Pacific cod indicated a discontinuity from strict allometric scaling
during the early larval stage.
As an overview, consider the chapter headings that start with 'Design and Strategies for Genome Mapping and Haplotyping; proceed through haplotyping in natural populations and experimental crosses, functional mapping, pharmacokinetics and pharmacodynamics (PK/PD), biological clocks, allometric scaling
, drug efficacy/toxicity/response and, finally, end with nonparametric and semiparametric functional mapping of drug response.
It represents a revival of allometric scaling
studies linking organismal metabolic rates to body mass--across several orders of magnitude--via temperature as the central factor (Gillooly et al.
They begin by setting out the fundamentals in such areas as pharmacokinetics and pharmacodynamics, analytical methods, allometric scaling
, and non-clinical aspects of therapeutic proteins.
is a powerful approach for studying the relationship between size, shape and function.
in three sizes of equids (equus eaballus).
infinity]], K) had consistently high ranks for their contribution to model variance, as did those describing the allometric scaling
of standard metabolic rate (SMRa, SMRb).
Using examples, he demonstrates how allometric scaling
in terms of pharmacokinetic parameters can be used to select a first-in-human dose in drug development.
In fact, the allometric scaling
of clearance appears to follow body weight raised to the three-quarters power, producing slightly less of a difference across species than that predicted by body surface area scaling, which is body weight raised to the two-thirds power (35).