alloimmunization

al·lo·im·mu·ni·za·tion

(al-lō'im-myū'nī-zā'shŭn),
Immunization against a non-self protein, as occurs in patients receiving transfusions.

alloimmunization

/al·lo·im·mu·ni·za·tion/ (-im″u-nĭ-za´shun) an immune response generated in an individual or strain of one species by an alloantigen from a different individual or strain of the same species.

al·lo·im·mu·ni·za·tion

(al-lō'im-myū'nī-zā'shŭn)
Immunization against a non-self protein, as occurs in patients receiving transfusions.

alloimmunization

development of antibodies in response to alloantigens; antigens derived from a genetically dissimilar animal of the same species. See also alloantigen.

alloimmunization of pregnancy
sensitization of the dam against fetal red blood cell antigens that leak into the maternal circulation across the placenta or during parturition is uncommon except in the mare and sow where it gives rise to alloimmune hemolytic anemia of the newborn.
References in periodicals archive ?
20) In some instances, such as in patients with GT, alloimmunization to platelet antigens occurs, and hemostatic support has to be provided with activated clotting factor concentrates.
In Rh-D alloimmunization newborns were often severely affected, unstable at birth, necessitated multiple exchange transfusions; thereby associated with extensive morbidity and mortality.
For example, despite matching the ABO blood group antigens during red blood cell (RBC) transfusion, up to 45 percent of chronically transfused patients, such as those with sickle cell disease or thalassemia, develop antibodies to mismatched minor antigens on transfused RBCs; this process is known as alloimmunization.
In the case of platelet transfusions (in patients less than 45 kg), alloimmunization shall be avoided, respecting the ABO platelet group (Grade D, Level 4).
Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization.
1) Rh alloimmunization in pregnancy develops when the maternal red blood cells (RBCs) lacking the Rh antigen (RhD negative) are exposed to RhD positive RBCs through the placenta leading to the activation of the maternal immune system.
Alloimmunization to human leukocyte antigen (HLA) and/or platelet-specific antigens (HPA) is included in this category.
Characterization of Red Blood Cells Alloimmunization at Hospital Universitario del Valle between 2011 and 2013
The rate of alloimmunization is variable and depends on the frequency of the antigens in the population and on their immunogenicity.
Key Words: Beta Thalassaemia Major Multiple blood transfusions Alloimmunization.