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allograft |
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allograft /al·lo·graft/ (al´o-graft) a graft between individuals of the same species, but of different genotypes. Called also homograft.
Allograft Tissue that is taken from one person's body and grafted to another person. Mentioned in: Bone Grafting, Skin Grafting allograft [al′əgraft] Etymology: Gk, allos, other + graphion, stylus surgical transplantation of tissue between two genetically dissimilar individuals of the same species, such as between two humans who are not monozygotic twins. Tissues commonly used for allografts include cornea, cartilage, bone, artery, and cadaver skin stored in a skin-tissue bank. Also called allogenic graft, homogenous graft, homograft, homologous graft. Compare autograft, isograft, xenograft. See also graft. allograft a graft between individuals of the same species, but of a different genotype. Formerly called homograft. allograft rejection see rejection. allograft Allogeneic graft Immunology A graft–organ, tissues, or cells donated from a genetically distinct–in humans, allogeneic at one or more MHC loci—individual of the same species. See Renal transplantation. Cf
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Although allograft rejection is only the second leading cause of mortality for cardiac transplant recipients, immunosuppression is the primary source of morbidity. In 2004, XDx completed the validation phase of the CARGO (Cardiac Allograft Rejection and Gene Expression Observational) study in anticipation of a December 2004 launch of AlloMap molecular expression testing, the company's molecular expression test targeting the post-cardiac transplantation patient management market. of the US Food and Drug Administration (FDA) has granted the Company "Orphan Drug Designation" for its investigational antibodies to interferon-gamma to treat Immunologic Corneal Allograft Rejection. |
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