allograft rejection


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al·lo·graft re·jec·tion

the rejection of tissue transplanted between two genetically different individuals of the same species. The rejection is caused by T lymphocytes responding to the foreign major histocompatibility complex of the graft.

al·lo·graft re·jec·tion

(al'lō-graft rĕ-jek'shŭn)
The rejection of tissue transplanted between two genetically different individuals of the same species. Rejection is caused by T lymphocytes responding to the foreign major histocompatibility complex of the graft.

allograft

a graft between individuals of the same species, but of a different genotype. Formerly called homograft.

allograft rejection
References in periodicals archive ?
Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: a contribution of humoral immunity to chronic allograft rejection.
Histologic grading of acute allograft rejection in pancreas needle biopsy: correlation to serum enzymes, glycemia, and response to immunosuppressive treatment.
The study analyzed data from heart transplant recipients participating in the Cardiac Allograft Rejection Gene Expression Observational Study (CARGO), which was conducted at eight US transplant Centers, Health Day News reported.
Article topics include an overview of the involvement of stress proteins in renal diseases and the relationship to glomerular epithelial cell injury, responses of renal medullary cells to osmotic stress, heat shock proteins in renal cell carcinomas, heat shock protein 47 and renal fibrogenesis, cytoprotective effects of heme oxygenase in acute renal failure, cisplatin-associated nephrotoxicity and pathological events, heat shock proteins and allograft rejection, and oxidant stress in renal pathophysiology.
Low MPA-AUC values estimated with an abbreviated sampling schedule and a validated HPLC procedure were found to be associated with cardiac allograft rejection in heart transplant recipients (12).
In the first study, which received a conference Young Investigator Award, researchers sought to determine whether sCD83 can suppress an anti-donor antibody response and prevent chronic kidney allograft rejection in a preclinical model of transplantation that compared sCD83 to a sub-therapeutic dose of cyclosporine A.
LONDON, April 30 /PRNewswire/ -- Astellas announced today that the European Commission has approved the immunosuppressant Advagraf(R) (generic name: tacrolimus, prolonged release) for prophylaxis of transplant rejection in adult kidney or liver allograft recipients and for the treatment of allograft rejection resistant to treatment with other immunosuppressive drugs in adult patients throughout the European Union (EU).
Novartis says patients who undergo MMF reduction are 8 times more likely to suffer acute allograft rejection than those who don't have dose reduction.
The AlloMap test was developed utilizing samples and clinical data from the Cardiac Allograft Rejection Gene expression Observational study.
Los Angeles, CA, announced the FDA's Office of Orphan Products Development (OPD) has granted the company Orphan Drug Designation for its investigational antibodies to interferon-gamma to treat immunologic corneal allograft rejection.