allele frequency

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allele frequency

A term used in population genetics for the number of copies of a particular allele divided by the number of copies of all alleles at that specific genetic locus in a population of interest. Allele frequency is a measure of a population’s genetic diversity: the higher the allele frequency, the greater the population’s consanguinity.
Allele frequencyclick for a larger image
Fig. 23 Allele frequency . Calculation of allele frequency from genotype frequency.

allele frequency

or

gene frequency

the proportion of a particular ALLELE of a gene in a population, relative to other alleles of the same gene. For example, if a gene has two alleles, A and a , and the frequency of A is 0.6, then the frequency of a will be 1.0 - 0.6 = 0.4. The allele frequency can be calculated from the GENOTYPE FREQUENCY; See Fig. 23 .
References in periodicals archive ?
This first version includes 26 major cancer 'hotspot' genes, all at 20% allelic frequency and quantitated using digital PCR to ensure highest accuracy.
Generally, the allelic frequencies of wild-type allele were higher than those of the mutation-type allele in each breed, and also there was a plain tendency in the allelic frequency of the native and foreign breeds i.
In addition to high TNF-[alpha] concentration, this study showed a cross-sectional association between allelic frequency and markers of HIV disease progression, which was indicated by high bystander [T.
The allelic frequency ranges from 3% to 21%, depending on ethnicity (6).
There may be important differences in the allelic frequency of these mutations in different European populations, and they may exhibit regional variations in Europe (7-10).
In this method no significant differences observed in allelic frequency and observed heterozygosity between breeders and their progenies, to keep the level of heterozigocity may is due to the method of crossing.
The present study aims to determine the allelic frequency of SNPs across intracellular folate metabolic pathway in healthy Indian subjects.
The maximum likelihood estimate for the inferred null allelic frequency was calculated for each locus using ML-NullFreq (Kalinowski & Taper 2006).
This increase of allelic frequency is better reflected in changes in antigenic profiles.
The CYP2C9*2 allele occurs at an allelic frequency of ~10% in Caucasian subjects and 2% to 4% in African-American subjects and has not been reported in Asian populations.