A meta-analysis of 20 randomized controlled trials, published on September 12, 2012, in the Journal of the American Medical Association, concluded that supplementation with omega-3 polyunsaturated fatty acids (the main biologically active constituents of fish oil) "was not associated with a lower risk of all-cause mortality
, cardiac death, sudden death, myocardial infarction, or stroke.
In contrast, although the insulin concentration for the entire study population was not associated with a higher risk of all-cause mortality
The adjusted hazard ratio (HR) for all-cause mortality
in all vegetarians combined vs.
Patients who had notably high or notably low sodium intake levels were at an increased risk of both all-cause mortality
and cardiovascular disease, compared with patients who had usual sodium intake levels, a new meta-analysis suggests.
Using a mendelian randomization design circumventing confounding (15, 16), we first tested whether low nonfasting triglyceride concentrations were associated with reduced all-cause mortality
in observational analyses; second, whether variants in the triglyceride-degrading enzyme lipoprotein lipase, causing reduced concentrations of nonfasting triglycerides and remnant cholesterol, were associated with reduced all-cause mortality
in genetic analyses.
Results of a new study dispute the hypothesis that calcium supplementation, with or without vitamin D, increases coronary heart disease or all-cause mortality
risk in elderly women.
Key clinical point: Diabetic immigrants to Ontario from low-income countries appear to have a lower risk of cardiovascular events and all-cause mortality
than do long-term or lifetime residents with diabetes.
No association between any measure of calcified plaque and calcium intake from diet or supplements was observed, nor was increased calcium intake associated with a greater risk of all-cause mortality
The researchers found no association between sodium intake and risk of overt nephropathy, diabetic retinopathy, or all-cause mortality
Oophorectomy had a profound protective effect on all-cause mortality
and cancer-specific mortality, both for BRCAl carriers and for BRCA2 carriers.
In the SECURE study (a study of 516 patients), CRESEMBA demonstrated non-inferiority to voriconazole on the primary endpoint of all-cause mortality
at day 42 for the treatment of adult patients with invasive aspergillosis or other filamentous fungi.
In the article "Effect of Drinking on All-Cause Mortality
in Women Compared with Men: A Meta-Analysis," Chao Wang and coauthors, Chinese Academy of Medical Sciences and Peking Union Medical Sciences (Beijing, China), modeled the relationship between the dose of alcohol consumed and the risk of death, comparing the results for drinkers versus non-drinkers and among male and female drinkers.