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One current topic of investigation is the transcription response of mice with different DNA alkylation repair capabilities upon exposure to alkylating agents.
The news came as a shock to scientists, who had believed that the response to alkylating agents was limited solely to DNA repair genes.
CASE STUDY: IDENTIFICATION OF IN VITRO METABOLITE/DECOMPOSITION PRODUCTS OF THE NOVEL DNA ALKYLATING AGENT LAROMUSTINE (Ala F.
The latency between previous cancer treatment and leukemia development is longer after alkylating agents (3-8 years) and shorter after topoisomerase II inhibitors (2-3 years).
25) However, both alkylating agents are associated with serious side effects such as anaemia, teratogenicity, thrombocytopenia, infertility, infection, and in the case of cyclophosphamide, the development of secondary malignancies.
Alkylating agents, for example, are more likely to contribute to the development of leukemia than cisplatin or carboplatin.
Besides corticosteroids, long-term treatment options for the treatment of JIA-associated uveitis include antimetabolites, alkylating agents and biologic agents.
Exposure to multiagent chemotherapy, particularly alkylating agents, may potentiate the effect of previous radiation therapy in childhood and thus serve as another predisposing factor for the development of a postradiation sarcoma [12].
The major medications used for chemotherapy include various combinations of the following agents: the immunomodulators thalidomide and lenalidomide; the proteasome inhibitor bortezomib; the alkylating agents melphalan and cyclophosphamide; and the steroids dexamethasone and prednisone.
This is especially true for women who may be receiving gonadotoxic therapies, such as alkylating agents or abdominal/pelvic radiation.
He begins with the reagents and processes: alkylating agents, acylating agents, nitration and nitrosylation, oxidation, and modifying proteins with reducing agents.
Our study showed that these alkylating agents are present at levels sufficient to cause DNA damage and could potentially have adverse implications to human health, particularly in the case of the development of oral cancer for BQ chewers," they said.