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alkylate
(redirected from alkylating)

    Also found in: Dictionary/thesaurus, Encyclopedia 0.01 sec.
alkylate [al´kĭ-lāt]
to cause the substitution of an alkyl group for an active hydrogen atom in an organic compound; see also alkylating agents.
alkylate
to treat with an alkylating agent.
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Cisplatin was the first drug to be discovered in the class of alkylating agents {it was discovered about 30 years ago}and it has more side effects than the newer generations of alkylating agents, so most doctors would have tried to use one of the newer chemotherapy agents before recommending treatment with Cisplatin.
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The drug is currently not approved for the treatment of multiple sclerosis but is indicated for treating B-cell chronic lymphocytic leukemia in patients who have been treated with alkylating agents and who have failed fludarabine therapy.
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TEMODAL (temozolomide) Capsule is an oral, cytotoxic alkylating agent indicated for treating glioblastoma multiforme (GBM).
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