In our study, no difference was observed between the patients who received only anthracycline and the patients who received anthracycline and alkalinizing agent or the patients who did not receive anthracycline treatment and received only alkalinizing agent in terms of cardiotoxicity.
Total doses of anthracycline and alkalinizing agents given to the patients with a diagnosis of Hodgkin lymphoma were calculated.
On the other hand, cardiotoxicity cases are reported in patients who use usual doses of alkalinizing agents, although cardiomyopathy is known to develop especially in patients with bone marrow transplant following treatment with high doses of alkalinizing agents (14).
Thus, ingestion of alkalinizing agents mentioned above by increasing the extracellular pH may create a favourable pH gradient for efflux of intracellular lactate and [H.
Numerous studies have assessed the effect of preexercise administration of alkalinizing agents on performance in different types of exercise (Burke et al.