alkaline hematin method

alkaline hematin method

An obsolete colorimetric technique for estimating the blood haemoglobin concentration based on the formation of hematin from haemoglobin, using 0.1 mol NaOH.
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The study's primary endpoint was a composite design where subjects had to achieve a menstrual blood loss (MBL) volume of less than 80 mL as well as a 50 percent or greater reduction in MBL volume from baseline at the final study month as measured by the alkaline hematin method.
The primary endpoint in Phase 3 studies will be the same as that employed in the Phase 2b study; percent of subjects with reduction in uterine blood flow as measured by the alkaline hematin method.
The mean change in menstrual blood loss volume, as quantified using the alkaline hematin method, was--353 mL in the E2V/DNG arm vs.
HMB was defined as mean menstrual blood loss greater than 80 mL per cycle, averaged over 2 cycles and measured by a validated alkaline hematin method.
The following results of the oral tranexamic acid formulation (LYSTEDA) were reported from two multicenter, double-blind, placebo-controlled, parallel-group trials of women aged 18-49 years with HMB, defined as mean menstrual blood loss (MBL) greater than 80 mL per cycle, averaged over two cycles and measured by a validated alkaline hematin method.
MBL was measured during 2 baseline and 3 treatment cycles using a validated alkaline hematin method.