Aleutian Mink Disease

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A chronic fatal parvoviral infection of minks, which causes a polyclonal expansion of B lymphocytes, and affects minks that are homozygous for the Aleutian blue mink gene

Aleutian mink disease

a slowly progressive disease of certain mink (e.g. Aleutian mink which are mutants for a pale colored pelt) caused by persistent parvovirus infection and associated with polyclonal, virus specific hypergammaglobulinemia and immune complex-mediated lesions, especially arteritis and glomerulonephritis. It is manifested by emaciation, reproductive inefficiency and death from renal failure. The characteristic laboratory findings are hypergammaglobulinemia and a massive proliferation and infiltration of plasma cells into the swollen kidneys and into the spleen, liver, lymph nodes and bone marrow.

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