aldosterone antagonist


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Related to aldosterone antagonist: potassium sparing diuretics

aldosterone

 [al-dos´ter-ōn, al´do-ster-ōn″]
the main mineralocorticoid hormone secreted by the adrenal cortex, the principal biological activity of which is the regulation of electrolyte and water balance by promoting the retention of sodium (and, therefore, of water) and the excretion of potassium; the retention of water induces an increase in plasma volume and an increase in blood pressure. Its secretion is stimulated by angiotensin II.
aldosterone antagonist a compound that blocks the action of aldosterone; the group includes potassium sparing diuretics such as spironolactone that compete with aldosterone for receptor sites, thus blocking the aldosterone-dependent exchange of sodium and potassium in the distal tubule.

al·dos·ter·one an·tag·o·nist

an agent that opposes the action of the adrenal hormone aldosterone on renal tubular mineralocorticoid retention; these agents, for example, spironolactone, are useful in treating the hypertension of primary hyperaldosteronism or the sodium retention of secondary hyperaldosteronism.

al·dos·ter·one an·tag·o·nist

(al-dos'tĕr-ōn an-tag'ŏ-nist)
An agent that opposes the action of the adrenal hormone aldosterone on renal tubular mineralocorticoid retention; these agents (e.g., spironolactone) are useful in treating the hypertension of primary hyperaldosteronism, or the sodium retention of secondary hyperaldosteronism.

al·dos·ter·one an·tag·o·nist

(al-dos'tĕr-ōn an-tag'ŏ-nist)
Agent that opposes action of the adrenal hormone aldosterone on renal tubular mineralocorticoid retention.
References in periodicals archive ?
A-HeFT randomized 1,050 African-American patients with NYHA class III or IV HF already treated with an ACEI or ARB, beta blocker and aldosterone antagonists to therapy with isosorbide dinitrate (target dose of 40 mg three times a day) and hydralazine (target dose 75 mg three times a day) in a combination tablet or placebo.
In the first study, researchers said "landmark clinical trials" had shown the aldosterone antagonists spironolactone and eplerenone cut deaths by up to 30% and readmissions for HF by nearly 40% in patients who had heart failure accompanied by reduced ejection fraction.
4 Percentage of patients who receive other aldosterone antagonist drugs for the treatment of Hypertension
While cardiovascular agents, such as aldosterone antagonists, are proven effective in heart failure and chronic kidney disease, their use is limited by the risk and incidence of uncontrolled elevated potassium levels that can lead to serious consequences.
Still, aldosterone antagonists remain underutilized in heart failure patients in Europe as well as the United States.
The current findings have the potential to greatly expand the use of aldosterone antagonists, which are now utilized by fewer than two-thirds of patients with heart failure in the United States with a current indication.
Specifically, of those patients eligible, only 38 percent received a CRT device, 49 percent received an ICD, and 34 percent received aldosterone antagonist drug therapy.
We found that some of the available medications may not be as effective in women, while other therapies, for example, beta blockers, aldosterone antagonists and pacemakers, may be very beneficial," said Dr.
Specifically, the guidelines recommend that aldosterone antagonists be used in addition to ACE inhibitors, beta-blockers and diuretics in advanced heart failure, and in addition to ACE inhibitors and beta-blockers in heart failure after heart attack with LVSD and signs of heart failure or diabetes.
Patients also faced excess risks of upper Cl bleeding when they took corticosteroids, aldosterone antagonists, or anticoagulants together with low-dose aspirin or nonselective NSAIDs, although the effect was not seen for COX-2 inhibitors, said Dr.
Aldosterone antagonists, such as spironolactone or eplerenone, provide additional blockage.
report significant synergy (more than additive risk) of traditional NSAIDs with corticosteroids, SSRIs, aldosterone antagonists, and antithrombotic agents other than low-dose aspirin (although risk was increased with traditional NSAIDs plus low-dose aspirin).