aldosterone


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Related to aldosterone: spironolactone, vasopressin, renin, hyperaldosteronism, ADH, antidiuretic hormone, Aldosterone antagonist

aldosterone

 [al-dos´ter-ōn, al´do-ster-ōn″]
the main mineralocorticoid hormone secreted by the adrenal cortex, the principal biological activity of which is the regulation of electrolyte and water balance by promoting the retention of sodium (and, therefore, of water) and the excretion of potassium; the retention of water induces an increase in plasma volume and an increase in blood pressure. Its secretion is stimulated by angiotensin II.
aldosterone antagonist a compound that blocks the action of aldosterone; the group includes potassium sparing diuretics such as spironolactone that compete with aldosterone for receptor sites, thus blocking the aldosterone-dependent exchange of sodium and potassium in the distal tubule.

al·dos·ter·one

(al-dos'tĕr-ōn), Avoid the mispronunciation aldoster'one.
A mineralocorticoid hormone produced by the zona glomerulosa of the adrenal cortex; its major action is to facilitate potassium exchange for sodium in the distal renal tubule, causing sodium reabsorption and potassium and hydrogen loss; the principal mineralocorticoid. It exists in equilibrium with the aldehyde form.

aldosterone

/al·dos·ter·one/ (al-dos´ter-ōn) the major mineralocorticoid hormone secreted by the adrenal cortex. It promotes the retention of sodium and bicarbonate, the excretion of potassium and hydrogen ions, and the secondary retention of water. Large excesses can invoke plasma volume expansion, edema, and hypertension.

aldosterone

(ăl-dŏs′tə-rōn′)
n.
A steroid hormone that is produced by the adrenal cortex and regulates salt balance, blood volume, and blood pressure in the body.

aldosterone

[al′dōstərōn′, aldos′tərōn]
a mineralocorticoid steroid hormone produced by the adrenal cortex with action in the renal tubule to retain sodium, conserve water by reabsorption, and increase urinary excretion of potassium.

aldosterone

An adrenocortical mineralocorticoid that controls electrolyte and water homeostasis by regulating reabsorption of Na+ and Cl– in exchange for K+ and H+, and which maintains blood pressure and blood volume. Aldosterone secretion is controlled by the RAA system and by concentrations of K+ in the circulation, which if increased evokes secretion of aldosterone. Reduced Na+ evokes renin release, which stimulates aldosterone secretion; aldosterone may be measured when evaluating hypertension.

Increased in
Adrenocortical adenoma or carcinoma, bilateral adrenal hyperplasia, renovascular hypertension, liver disease, congestive heart failure, cirrhosis, nephrotic syndrome, pregnancy (3rd trimester).

Decreased in
Primary hypoaldosteronism, salt-losing syndrome, eclampsia/toxemia of pregnancy, Addison’s disease (chronic adrenal insufficiency).
 
Ref range
• Serum, ≤ 20 mg/dL.
• Urine, ≤ 20mg/24 hours.

aldosterone

Endocrinology An adrenocortical mineralocorticoid hormone that controls the body's electrolyte and water homeostasis by regulating reabsorption of Na+ and Cl– in exchange for K+ and H+ ions, and maintaining BP and blood volume; aldosterone secretion is controlled by the RAA system and by concentrations of K+ in the circulation, which if ↑, evokes secretion of aldosterone; ↓ Na+ evokes renin release, which stimulates aldosterone secretion; aldosterone may be measured when evaluating HTN; aldosterone is ↑ in adrenocortical adenoma or CA, bilateral adrenal hyperplasia, renovascular HTN, liver disease, CHF, cirrhosis, nephrotic syndrome, pregnancy–3rd trimester; it is ↓ in 1º hypoaldosteronism, salt-losing syndrome, toxemia of pregnancy, Addison's disease Ref range Serum, ≤ 20 mg/dL; ≤ 20mg/24hrs, urine. See Hypertension, Pseudoaldosterone, Timed collections.

al·dos·ter·one

(al-dos'tĕr-ōn)
A hormone produced by the cortex of the suprarenal gland; its major action is to facilitate potassium exchange for sodium in the distal renal tubule, causing sodium reabsorption and potassium and hydrogen loss; the principal mineralocorticoid.

aldosterone

One of the STEROID hormones produced by the outer part of the adrenal gland. Aldosterone is concerned with the control of salt and water loss in the urine.

aldosterone

a hormone of the cortex of the ADRENAL GLAND. It is responsible for the relative concentration of sodium and potassium ions in the body. It promotes the reabsorption of sodium ions from the ascending limb of the LOOP OF HENLE in the kidney, with the elimination of potassium ions, and increases the uptake of sodium ions by the alimentary canal. The concentration of sodium ions in the blood thus rises and potassium ions fall, making possible the ionic regulation of body fluids (see SODIUM PUMP).

Aldosterone

A hormone secreted by the adrenal glands that is important for maintaining salt and water balance in the body.

aldosterone

hormone secreted by the adrenal glands, at a rate regulated by the level of sodium in body fluids. Acts in the kidneys to enhance reabsorption of sodium, reducing its loss in the urine. Similar action on sweat glands reduces sodium loss when sweating rate is high. See also hormones; Table 1.
Table 1: Hormones
Site of productionName of hormoneMain targetsInvolved in regulating:Secretion controlled by:
HypothalamusReleasing and inhibiting hormonesAnterior pituitary (via local blood vessels)Secretion of anterior pituitary hormonesOther brain regions; feedback re regulated hormones and their actions
Neurohormones released from posterior pituitary:
OxytocinUterus, breastsLabour and lactationAfferent information from target organs
Antidiuretic hormone (ADH, vasopressin)KidneysWater loss: ECF volume and osmolalityHypothalamic osmoreceptors
Anterior pituitary(Human) growth hormone (H)GHMost cellsGrowth and metabolismHypothalamic releasing and inhibiting hormones via local blood vessels
ProlactinBreastsMilk production
Trophic hormones:
Thyroid-stimulating (TSH)Thyroid glandThyroid secretions
GonadotrophinsOvary or testisGerm cell maturation and hormone secretions
Adrenocorticotrophic (ACTH)Adrenal cortexCortisol secretion
Pineal bodyMelatoninWidespread, including brain, thymus, etc.
  • Sleep/wake cycle
  • Antioxidant
  • Immune system
Hypothalamus; varying light input from retina
Thyroid
  • Thyroxine
  • Triiodothyronine
  • Calcitonin
  • Most cells
  • Bone, kidneys, gut
  • Cellular oxidative metabolism
  • Decreases ECF [Ca2+]
  • TSH from anterior pituitary. Negative feedback from blood hormone concentration
  • ECF [Ca2+]
ParathyroidsParathormoneBone, kidneys, gut
  • Calcium and phosphorus absorption, secretion and turnover in bone.
  • Increases ECF [Ca2+]
ECF [Ca2+]
Adrenal: Cortex
  • Cortisol
  • Aldosterone
  • Androgens
  • Most cells
  • Kidneys
  • Gonads & other tissues
  • Metabolism
  • Response to stress
  • Na and K balance
  • Sex characteristics and reproductive function
  • ACTH from anterior pituitary
  • ECF [Na+] [K+]
  • Renin-angiotensin
  • ACTH
Medulla
  • Adrenaline
  • Noradrenaline
Heart, smooth muscle, glandsCardiovascular and metabolic adjustments to activity and stressSympathetic nervous system
Atrial wallAtrial natriuretic hormoneKidneysBlood volume; increases sodium (therefore also water) loss in urineStretch of atrial wall by venous pressure
Gonads: TestisAndrogens (mainly testosterone)Genitalia and other tissuesReproductive function and sex characteristicsAnterior pituitary gonadotrophins
Ovary
  • Oestrogens
  • Progesterone
Uterus, breasts and other tissuesMenstrual cycle, pregnancy, lactation
Pancreas
  • Insulin, glucagon
  • Somatostatin
  • Most cells
  • Other secretory cells in the pancreas
Blood levels, storage and cellular uptake of nutrients, notably glucose, but also proteins and fatsBlood levels of nutrients; autonomic nervous system; other gastrointesinal hormones
Alimentary tract
StomachGastrinGastric acid-secreting cellsGastrointestinal functions: motility, digestive juices and other secretionsLocal chemical and mechanical factors in the alimentary tract
Small intestine
  • Secretin
  • Cholecystokinin- pancreozymin (CCK-PZ)
  • Somatostatin, motilin
  • Other peptide hormones including vasoactive intestinal peptide (VIP)
  • Widespread on
  • GI tract
Several GI functions including bile flow, pancreatic enzyme and exocrine secretionsIngestion of food, distension of GI tract

aldosterone

adrenal mineralocorticoid hormone; causes retention of sodium (Na+) and excretion of unwanted potassium (K+) and hydrogen (H+) ions via urine

aldosterone (al·dsˑ·t·rōn),

n an adrenal hormone that causes elevation of blood pressure through the retention of sodium and the resultant increase in blood plasma volume.

al·dos·ter·one

(al-dos'tĕr-ōn) Avoid the mispronunciation aldoster'one.
Mineralocorticoid hormone produced by the zona glomerulosa of the cortex of the suprarenal gland that facilitates potassium exchange for sodium in the distal renal tubule, causing sodium reabsorption and potassium and hydrogen loss.

aldosterone (aldos´tərōn),

n an adrenal corticosteroid hormone that acts primarily to accelerate the exchange of potassium for sodium in the renal tubules and other cells. It is a potent mineralocorticoid but also has some regulatory effect on carbohydrate metabolism.

aldosterone

the main mineralocorticoid hormone secreted by the adrenal cortex, the principal biological activity of which is the regulation of electrolyte and water balance by promoting the retention of sodium (and, therefore, of water) and the excretion of potassium; the retention of water induces an increase in plasma volume and an increase in blood pressure. Its secretion is stimulated by angiotensin II. Deficiency is hypoadrenocorticism (Addison's disease).
References in periodicals archive ?
If anyone in this room who doesn't have primary aldosteronism had a high-salt diet for 3 days and we did a 24-hour urine on the third day, your aldosterone would be zero.
They drew each subject's early morning blood level of aldosterone after an overnight fast.
9) In addition to classical genomic signaling effects of the aldosterone-MR complex, there is increasing evidence of rapid non-transcriptional effects of aldosterone that increase systemic vascular resistance as well.
It might be a good idea to consider early on drugs that target aldosterone in these individuals," said Diana G.
Typically, KCNJ5 appears to help normalize the levels of the sodium-retaining hormone Aldosterone by regulating how much potassium is pumped in and out of Aldosterone-producing cells which are located on the outer layer of the adrenal glands.
The test for Conn's involves taking blood from a vein supplying the adrenal gland to measure levels of aldosterone.
We wanted to understand whether aldosterone also increases the nerve activity that causes constriction of blood vessels, which elevates blood pressure in humans.
Contrasting associations between aldosterone synthase gene polymorphisms and essential hypertension in blacks and in whites.
The parameters analyzed in the study were plasma glucose, total protein, total cholesterol, melatonin, cortisol, corticosterone, aldosterone, and insulin.
5 mIU/l (low), aldosterone was 2 234 pmol/l (high) and her transtubular potassium gradient was 17 (high).
the angiotensin converting enzyme stimulates aldosterone production