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Related to aldosterone: spironolactone, vasopressin, renin, hyperaldosteronism, ADH, antidiuretic hormone, Aldosterone antagonist
the main mineralocorticoid hormone secreted by the adrenal cortex, the principal biological activity of which is the regulation of electrolyte and water balance by promoting the retention of sodium (and, therefore, of water) and the excretion of potassium; the retention of water induces an increase in plasma volume and an increase in blood pressure. Its secretion is stimulated by angiotensin II.
aldosterone antagonist a compound that blocks the action of aldosterone; the group includes potassium sparing diuretics such as spironolactone that compete with aldosterone for receptor sites, thus blocking the aldosterone-dependent exchange of sodium and potassium in the distal tubule.
al·dos·ter·one(al-dos'tĕr-ōn), Avoid the mispronunciation aldoster'one.
A mineralocorticoid hormone produced by the zona glomerulosa of the adrenal cortex; its major action is to facilitate potassium exchange for sodium in the distal renal tubule, causing sodium reabsorption and potassium and hydrogen loss; the principal mineralocorticoid. It exists in equilibrium with the aldehyde form.
aldosterone/al·dos·ter·one/ (al-dos´ter-ōn) the major mineralocorticoid hormone secreted by the adrenal cortex. It promotes the retention of sodium and bicarbonate, the excretion of potassium and hydrogen ions, and the secondary retention of water. Large excesses can invoke plasma volume expansion, edema, and hypertension.
A steroid hormone that is produced by the adrenal cortex and regulates salt balance, blood volume, and blood pressure in the body.
a mineralocorticoid steroid hormone produced by the adrenal cortex with action in the renal tubule to retain sodium, conserve water by reabsorption, and increase urinary excretion of potassium.
aldosteroneAn adrenocortical mineralocorticoid that controls electrolyte and water homeostasis by regulating reabsorption of Na+ and Cl– in exchange for K+ and H+, and which maintains blood pressure and blood volume. Aldosterone secretion is controlled by the RAA system and by concentrations of K+ in the circulation, which if increased evokes secretion of aldosterone. Reduced Na+ evokes renin release, which stimulates aldosterone secretion; aldosterone may be measured when evaluating hypertension.
Adrenocortical adenoma or carcinoma, bilateral adrenal hyperplasia, renovascular hypertension, liver disease, congestive heart failure, cirrhosis, nephrotic syndrome, pregnancy (3rd trimester).
Primary hypoaldosteronism, salt-losing syndrome, eclampsia/toxemia of pregnancy, Addison’s disease (chronic adrenal insufficiency).
• Serum, ≤ 20 mg/dL.
• Urine, ≤ 20mg/24 hours.
aldosteroneEndocrinology An adrenocortical mineralocorticoid hormone that controls the body's electrolyte and water homeostasis by regulating reabsorption of Na+ and Cl– in exchange for K+ and H+ ions, and maintaining BP and blood volume; aldosterone secretion is controlled by the RAA system and by concentrations of K+ in the circulation, which if ↑, evokes secretion of aldosterone; ↓ Na+ evokes renin release, which stimulates aldosterone secretion; aldosterone may be measured when evaluating HTN; aldosterone is ↑ in adrenocortical adenoma or CA, bilateral adrenal hyperplasia, renovascular HTN, liver disease, CHF, cirrhosis, nephrotic syndrome, pregnancy–3rd trimester; it is ↓ in 1º hypoaldosteronism, salt-losing syndrome, toxemia of pregnancy, Addison's disease Ref range Serum, ≤ 20 mg/dL; ≤ 20mg/24hrs, urine. See Hypertension, Pseudoaldosterone, Timed collections.
A hormone produced by the cortex of the suprarenal gland; its major action is to facilitate potassium exchange for sodium in the distal renal tubule, causing sodium reabsorption and potassium and hydrogen loss; the principal mineralocorticoid.
aldosteroneOne of the STEROID hormones produced by the outer part of the adrenal gland. Aldosterone is concerned with the control of salt and water loss in the urine.
aldosteronea hormone of the cortex of the ADRENAL GLAND. It is responsible for the relative concentration of sodium and potassium ions in the body. It promotes the reabsorption of sodium ions from the ascending limb of the LOOP OF HENLE in the kidney, with the elimination of potassium ions, and increases the uptake of sodium ions by the alimentary canal. The concentration of sodium ions in the blood thus rises and potassium ions fall, making possible the ionic regulation of body fluids (see SODIUM PUMP).
A hormone secreted by the adrenal glands that is important for maintaining salt and water balance in the body.
Mentioned in: Congenital Adrenal Hyperplasia
aldosteronehormone secreted by the adrenal glands, at a rate regulated by the level of sodium in body fluids. Acts in the kidneys to enhance reabsorption of sodium, reducing its loss in the urine. Similar action on sweat glands reduces sodium loss when sweating rate is high. See also hormones; Table 1.
|Site of production||Name of hormone||Main targets||Involved in regulating:||Secretion controlled by:|
|Hypothalamus||Releasing and inhibiting hormones||Anterior pituitary (via local blood vessels)||Secretion of anterior pituitary hormones||Other brain regions; feedback re regulated hormones and their actions|
|Neurohormones released from posterior pituitary:|
|Oxytocin||Uterus, breasts||Labour and lactation||Afferent information from target organs|
|Antidiuretic hormone (ADH, vasopressin)||Kidneys||Water loss: ECF volume and osmolality||Hypothalamic osmoreceptors|
|Anterior pituitary||(Human) growth hormone (H)GH||Most cells||Growth and metabolism||Hypothalamic releasing and inhibiting hormones via local blood vessels|
|Thyroid-stimulating (TSH)||Thyroid gland||Thyroid secretions|
|Gonadotrophins||Ovary or testis||Germ cell maturation and hormone secretions|
|Adrenocorticotrophic (ACTH)||Adrenal cortex||Cortisol secretion|
|Pineal body||Melatonin||Widespread, including brain, thymus, etc.||Hypothalamus; varying light input from retina|
|Parathyroids||Parathormone||Bone, kidneys, gut||ECF [Ca2+]|
|Medulla||Heart, smooth muscle, glands||Cardiovascular and metabolic adjustments to activity and stress||Sympathetic nervous system|
|Atrial wall||Atrial natriuretic hormone||Kidneys||Blood volume; increases sodium (therefore also water) loss in urine||Stretch of atrial wall by venous pressure|
|Gonads: Testis||Androgens (mainly testosterone)||Genitalia and other tissues||Reproductive function and sex characteristics||Anterior pituitary gonadotrophins|
|Ovary||Uterus, breasts and other tissues||Menstrual cycle, pregnancy, lactation|
|Pancreas||Blood levels, storage and cellular uptake of nutrients, notably glucose, but also proteins and fats||Blood levels of nutrients; autonomic nervous system; other gastrointesinal hormones|
|Stomach||Gastrin||Gastric acid-secreting cells||Gastrointestinal functions: motility, digestive juices and other secretions||Local chemical and mechanical factors in the alimentary tract|
|Small intestine||Several GI functions including bile flow, pancreatic enzyme and exocrine secretions||Ingestion of food, distension of GI tract|
aldosteroneadrenal mineralocorticoid hormone; causes retention of sodium (Na+) and excretion of unwanted potassium (K+) and hydrogen (H+) ions via urine
n an adrenal hormone that causes elevation of blood pressure through the retention of sodium and the resultant increase in blood plasma volume.
al·dos·ter·one(al-dos'tĕr-ōn) Avoid the mispronunciation aldoster'one.
Mineralocorticoid hormone produced by the zona glomerulosa of the cortex of the suprarenal gland that facilitates potassium exchange for sodium in the distal renal tubule, causing sodium reabsorption and potassium and hydrogen loss.
n an adrenal corticosteroid hormone that acts primarily to accelerate the exchange of potassium for sodium in the renal tubules and other cells. It is a potent mineralocorticoid but also has some regulatory effect on carbohydrate metabolism.
the main mineralocorticoid hormone secreted by the adrenal cortex, the principal biological activity of which is the regulation of electrolyte and water balance by promoting the retention of sodium (and, therefore, of water) and the excretion of potassium; the retention of water induces an increase in plasma volume and an increase in blood pressure. Its secretion is stimulated by angiotensin II. Deficiency is hypoadrenocorticism (Addison's disease).