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aldose reductase inhibitor

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aldose reductase inhibitor
Clinical therapeutics Any of a family of compounds–eg, epalrestat, ponalrestat, sorbinil, tolrestat, which block aldose reductase; ↑ intracellular glucose leads to ↑ sorbitol, which competitively inhibits glomerular and neural synthesis of myo-inositol; the ↓ in myo-inositol synthesis depresses phosphoinositide metabolism, and ↓ in Na+K+-ATPase activity; ARIs do not prevent the complications of type 1 DM See Aldose reductase.


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However, mice fed a dose of aldose reductase inhibitor before inhaling ragweed extract showed dramatically reduced levels of these components of the asthmatic response.
Administration of ascorbic acid and an aldose reductase inhibitor (tolrestat) in diabetes: Effect on urinary albumin excretion.
In contrast, only a few molecules have been developed specifically for NP as a primary indication and these include an aldose reductase inhibitor, a membrane integrity agonist and an opioid kappa receptor agonist.
 
 
 
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