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aldose reductase

   Also found in: Acronyms, Wikipedia 0.01 sec.
aldose reductase
An enzyme normally present in the eye and elsewhere, which converts excess glucose–as occurs in DM—into sorbitol; excess sorbitol in the eye, nerves, and kidneys can lead to retinopathy, neuropathy, and nephropathy. See Aldose reductase inhibitors.


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Oral administration of aldose reductase inhibitors works effectively in experimental animals.
Excess glucose is metabolized by the enzyme aldose reductase to the polyol sorbitol, which is then metabolized by sorbitol dehydrogenase to fructose.
Aldose reductase blockers were able to prevent the development of diabetic cataracts in experimental studies, however clinical trials were interrupted due to unclear side effects.
 
 
 
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