aldose reductase


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al·dose re·duc·tase

polyol dehydrogenase (NADP+); an oxidoreductase that reversibly converts aldoses to alditols (for example, glucose to sorbitol) with NADPH as hydride donor, an important step in the metabolism of sorbitol and in the formation of diabetes-associated cataracts.
See also: d-sorbitol-6-phosphate dehydrogenase.

aldose reductase

An NADPH-dependent oxidoreductase (EC 1.1.1.21) that catalyses the reduction of various aldehydes and carbonyls (e.g., glucose into sorbitol), which is the first step in the polyol pathway of glucose metabolism. Excess sorbitol in the eye, nerves and kidneys in diabetics leads to retinopathy, neuropathy and nephropathy.

aldose reductase

An enzyme normally present in the eye and elsewhere, which converts excess glucose–as occurs in DM—into sorbitol; excess sorbitol in the eye, nerves, and kidneys can lead to retinopathy, neuropathy, and nephropathy. See Aldose reductase inhibitors.

aldose reductase

An enzyme that makes up part of the metabolic pathway that converts glucose to fructose and sorbitol. Fructose and sorbitol may damage nerves, the retina, and the lens of the eye when they accumulate excessively, e.g., in poorly controlled diabetes mellitus.
References in periodicals archive ?
Aldose reductase and cardiovascular diseases, creating human-like diabetic complications in an experimental model.
Using cell culture and laboratory mouse experiments, the researchers showed that the enzyme, aldose reductase, is essential to a process known as goblet cell metaplasia that is seen in both asthma and COPD.
Supplementation with vanadyl sulfate has been shown to reduce fasting glucose and glycosylated hemoglobin (86-88) In diabetic rats, treatment with sodium orthovanadate reversed the increased activity of polyol pathway enzymes aldose reductase and sorbitol dehydrogenase, the accumulation of sorbitol and fructose in the diabetic lens, and blood glucose and glycosylated hemoglobin levels.
The 3-isomangostin as one xanthone derivative showed a significant value in the inhibition of aldose reductase since its [IC.
So we thought, why not find out if aldose reductase inhibition also has an effect on asthma?
Study design: The 70% ethanolic extract of Balanites aegyptiaca fruit mesocarp and its fractions were screened for inhibition of the aldose reductase enzyme.
The inhibitory effect on aldose reductase by an extract of Ganoderma lucidum.
When blood sugar levels become elevated, aldose reductase is the enzyme that converts excess glucose into the sugar alcohol sorbitol.
Zenarestat is an aldose reductase inhibitor licensed from Fujisawa for the prevention of diabetic neuropathy.
monoclonal antibodies, MAbs,) for rheumatoid arthritis (RA) -- Disease modifying anti-rheumatic drugs (DMARDs) -- Non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids and aldose reductase inhibitors -- Understanding pain pathways and mechanisms of action -- Safety and patient compliance -- Clinical evidence supporting product efficacy
Aldose reductase blockers were able to prevent the development of diabetic cataracts in experimental studies, however clinical trials were interrupted due to unclear side effects.
chinensis effectively inhibited aldose reductase activity and suppressed sorbitol accumulation in STZ-induced diabetic rat tissues.