aldolase


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Related to aldolase: enolase, creatine kinase, Aldolase B, Aldolase Test

al·dol·ase

(al'dō-lās),
1. Generic term for aldehyde-lyase.
2. Name sometimes applied to fructose-1,6-bisphosphate aldolase.

aldolase

/al·do·lase/ (al´do-lās)
2. an enzyme that acts as a catalyst in the production of dihydroxyacetone phosphate and glyceraldehyde phosphate from fructose 1,6-bisphosphate. It occurs in several isozymes, one of which is deficient in hereditary fructose intolerance.

aldolase

(ăl′də-lās′)
n.
Any of a class of enzymes that reversibly catalyze the cleavage of carbon-carbon bonds, especially the cleavage of sugars into three-carbon fragments during glycolysis.

aldolase

[al′dəlās]
enzyme found in muscle tissue that catalyzes the step in anaerobic glycolysis involving the breakdown of fructose 1,6-biphosphate to glyceraldehyde 3-phosphate. The enzyme can also catalyze the reverse reaction. Normal adult findings are 3 to 8.2 Sibley-Lehninger units/dL or 22 to 59 mU at 37° C. See also glycolysis.

aldolase

Clinical chemistry A serum enzyme that cleaves fructose 1,6-diphosphate to dihydroxyacetone phosphate and glyceraldehyde-3-phosphate in the muscles to produce energy; aldolase is distributed in all tissues and ↑ in skeletal muscle disease or injury, metastatic CA, CML, megaloblastic anemia, hemolytic anemia, or infarction; it is measured in suspected myopathies, as the intensity of ↑ reflects the severity of disease; aldolase may also be ↑ early in Pts who later develop muscular dystrophy and can also be used to monitor steroid therapy in inflammatory myopathies Ref range 3.1-7.5 U/L; aldolase is ↑ in Duchenne's muscular dystrophy, dermatomyositis, polymyositis, trichinosis

Aldolase

An enzyme, found primarily in the muscle, that helps convert sugar into energy.
Mentioned in: Aldolase Test

aldolase

an enzyme involved in the Embden-Meyerhof or glycolytic pathway which reversibly catalyzes the reaction fructose-1,6-bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. Present in all cells and may be measured in the serum as an indicator of muscle, heart or liver disease. Called also ALS and ALD.
References in periodicals archive ?
We highlight the fact that a patient with HIV-associated polymyositis may have normal serum CK levels, and in this setting one should perform an EMG and/or a muscle biopsy or at least assess other muscle enzyme levels such as serum aldolase and myoglobin.
The multifunctional folic acid synthesis FAS gene of Pneumocystis carinii encodes dihydroneopterin aldolase, hydroxy methyl dihydroneopterin pyrophosphokinase and dihydropteroate synthase.
Levels of muscular enzymes CK, myoglobin, ALT, AST, LDH and aldolase were extremely elevated, and a urinalysis established the presence of myoglobulinuria.
Summary of idiopathic interstitial lung diseases (ILD) UIP NSIP DIP/RB-ILD Demographics 60s-80s; 40s-50s; 40s-50s; M = F Increased F > M Associated with risk with Associated smoking smoking with collagen vascular disease or with extrinsic allergic alveolitis History/course Long Subacute onset Subacute onset of asymptomatic of months to months to years period years (radiographic evidence); Several years progressive dyspnea Physical exam Velcro crackles Raynaud Crackles Clubbing sclerodactyly Clubbing Lab RF ANA, SCL-70 Jo-1 CK; aldolase Serum Ab to birds, organisms, etc Biopsy (3) Variable from Uniform pattern DIP: Uniform area to area of involvement intra-alveolar ("temporal of the lung in macrophages, heterogeneity" biopsies.
Proteins involved in cell cytoskeleton, cell intermediary metabolism, and cell signaling mechanism such as tubulin, pyruvate kinase, aldolase C, and glutamine synthetase were identified.
It was established that some antibodies and enzymes such as muscle aldolase retain their specific activity after immobilization on these sorbents [51].
In the R&D area, Cyanotech continues to pursue development of its unique, bio-engineered mosquitocide product and its aldolase catalytic antibody.
A lysine to arginine substitution at position 146 of rabbit aldolase A changes the ratedetermining step to Schiff base formation.
Hemolysis is an important source of preanalytical error and has been reported to influence many laboratory results, including potassium, sodium, calcium, phosphorus, magnesium, bilirubin, haptoglobin, total protein, aldolase, amylase, LD, aspartate aminotransferase (AST), alanine aminotransferase, alkaline phosphatase, acid phosphatase, [gamma]-glutamyl transferase, folate, and iron (2).
falciparum specific parasite lactate dehydrogenase (Pf-pLDH), Plasmodium vivax specific parasite lactate dehydrogenase (Pv-pLDH) or antigen common to the four Plasmodium species: pan-pLDH or aldolase [5,39].
Nearly all of the proteins altered in significant amounts were identified as enzymes associated with important metabolic pathways, such as alcohol dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Xaa-His dipeptidase, ornithine carbamoyltransferase, putative O-acetylserine lyase, enolase (2-phosphoglycerate dehydratase), fructose-bisphosphate aldolase, and cysteine synthase.
aldolase, aspartate transaminase, type 1 and type 5 lactate dehydrogenase isoenzymes, carbonic anhydrase III, myoglobin, troponin I, troponin T, and glutamate pyruvate transaminases).