alcohol dependence


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alcohol dependence

alcoholism

A condition characterised by a pathologic pattern of alcohol use causing a serious impairment in social or occupational functioning; also defined by the Joint Committee of the National Council on Alcoholism and Drug Dependence & the American Society of Addiction Medicine as a “primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterised by … distortions in thinking, most notably denial.” A simpler, operational definition is persistent drinking that interferes with the person’s health, legal position, interpersonal relationships, or means of livelihood. Alcoholism is characterised by the regular intake of ≥75 g/day of alcohol.
Chronic effects Co-morbidity due to portal hypertension, hepatic failure, hyperoestrogenemia, infections (especially pneumonia) which may be due to alcohol-induced suppression of various immune defences, psychosocial disruption, transient hyperparathyroidism with decreased Ca2+, decreased Mg2+, osteoporosis.
Epidemiology (UK) 9% are heavy drinkers, 2% problem drinkers, 1% alcoholics.
Statistics (US) Alcohol causes half a million hospital admissions/year, 17,000 psychiatric admissions, 80% of all fire-related deaths, 65% of serious head injuries, 50% of homicides, 40% of RTAs/MVAs, 33% of divorces, 33% child abuse cases, 30% of fatal accidents, 30% of domestic accidents, 8 million working days lost, £1.6 billion annual cost to society.
Criteria for alcohol dependence
• Drinking >10 units/day
• Tolerance to effects of high blood alcohol concentration
• Withdrawal symptoms on stopping or reducing consumption
• Compulsion to continue drinking despite the problems it causes
• Abnormal lab tests.
References in periodicals archive ?
The demographics, clinical profiles, and family history of alcohol dependence in both groups are depicted in tables 1 and 2, respectively.
68%) students who participated in our study reported experiencing one of these three alcohol problems, alcohol abuse, alcohol dependence, or problematic drinking.
A second ADH IB gene variant, the ADH IB *3 allele, has been related to lower rates of alcohol dependence in many but not all association studies (Edenberg 2007; Edenberg et al.
A total of 2464 genes were nominally associated with alcohol dependence in EAs (p < 0.
Using the current DSM-IV-TR criteria in the general population, the rate of alcohol dependence is now 5.
Tekmira is developing TKM-ALDH2, a systemically delivered RNAi therapeutic that utilizes Tekmira's lipid nanoparticle (LNP) delivery technology, for the treatment of Alcohol Dependence (AD).
depression and alcohol dependence have significant disability and suicidal risk and might have commonalities in coping strategies.
The frequency of alcohol consumption and the relationship between alcohol dependence and depression among a group of men.
We were able to examine if energy drink use was associated with alcohol dependence, after controlling for risk- taking characteristics," Amelia M.
genomes), would be expected to have a higher concordance rate for alcohol dependence than dizygotic twins, who on average share only half their genome.
The first deals with the consequences of alcohol use and the second, the role that personality factors of alcohol abusers and the bearing these factors have on issues such as the antecedents of alcohol dependence and the determinants of the varying outcomes in patients with alcohol dependence.

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