alarmin

alarmin

(a-lar'min)
Any molecule released from a damaged or diseased cell that stimulates an immune response. Heat-shock proteins, interleukin-1a, and nucleosomes are examples.
Synonym: endokine
References in periodicals archive ?
Analysis of the worms' secretions revealed that the molecule Heligmosomoides polygyrus alarmin release inhibitor (HpARI) blocked the signals between cells of the immune system that are associated with allergic responses.
2014) IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy.
IL-33 production by stromal cells in lymph nodes (LN) and spleen is crucial for efficient viral clearance, however, the precise cellular source and signals involved in secretion of this nuclear alarmin during viral infection are unknown.
As a typical alarmin, high mobility group box 1 (HMGB1) acts as an inflammatory mediator to participate in the pathogenesis of many kinds of autoimmune and inflammatory diseases.
12) The importance of IL-33 has been suggested in the strengthening of innate immunity and may act as an alarmin to activate the immune system following cell necrosis or apoptosis.
Gerekce olarak bir hasta alarmin kendisini uyandiramadigini ve diger hasta ise kablolardan duydugu rahatsizligi dile getirmis.
Granulysin activates antigen presenting cells through TLR4 and acts as an immune alarmin.
However, the immune-modulating cytokine and endogenous alarmin interleukin-33 is upregulated in skin exposed to inflammatory UVB radiation.
Alarmin amaci mesane doluluguna olan duyarliligin sartli bir refleksle arttirilmasi (31) ve /veya gece mesane depolama islevinin arttirilmasidir (32).