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alanine aminotransferase

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alanine aminotransferase /al·a·nine ami·no·trans·fer·ase/ (ah-me?no-trans´fer-as) alanine transaminase.
alanine aminotransferase
n. Abbr. ALT
See SGPT.

alanine aminotransferase
an enzyme that catalyzes the reversible transfer of an amino group in the reaction:
$$\hbox{alanine + 2-oxoglutarate \leftrightharpoonsarrow\,\! pyruvate + glutamate}$$
requiring the coenzyme pyridoxal phosphate. Abbreviated ALT. It is present in high concentrations in hepatocytes of dogs, cats and humans. The serum concentration is elevated, especially when there is acute damage to liver cells, as in viral or toxic hepatitis, and obstructive jaundice. Significant elevation of the serum levels of ALT is a specific indicator of liver damage only in small animals and primates. Called also glutamic-pyruvic transaminase (GPT).

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By day 4 of hospitalization, the patient's level of creatine phosphokinase had elevated to 146 266 U/L, the level of aspartate aminotransferase was 3082 U/L, the level of alanine aminotransferase was 1144 U/L, and the level of lactate dehydrogenase was 4687 U/L.
The laboratory results showed that alanine aminotransferase (ALT) and [gamma]-glutamyl transpeptidase levels were elevated about 1.
Other endpoints observed in the study were a 57 percent increase in liver glycogen and no changes in muscle glycogen or in levels of plasma insulin or alanine aminotransferase.
 
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