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akinetic mutism

   Also found in: Dictionary/thesaurus, Wikipedia, Hutchinson 0.09 sec.
akinetic mutism
n.
A syndrome characterized by the inability to speak, loss of voluntary movement, and apparent loss of emotional feeling. It is related to lesions of the upper brainstem.


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To ascertain the clinical features of prion diseases, we analyzed the patient's age at onset and duration of disease course, which was calculated as the interval between the onset and the appearance of the akinetic mutism state or death in the patients who died without akinetic mutism.
Symptoms include nausea, headache, weakness, irritability, confusion, visual disturbances, parkinsonism, persistent vegetative state, akinetic mutism, agnosia, apraxia, confabulation, depression, delirium, and psychosis (8).
Masters proposed that probable CJD may be diagnosed in patients with rapidly progressive dementia, biphasic or triphasic waves on EEG, and at least two of myoclonus, visual or cerebellar symptoms, pyramidal or extrapyramidal signs, and akinetic mutism (14).
 
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