airway remodeling


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airway remodeling

Pathological changes in bronchi and bronchioles that occur in chronic asthma. These include increases in airway collagen, airway smooth muscle, and goblet cells.pickup.
See also: remodeling
References in periodicals archive ?
Many of the fibroblast responses that occur in airway remodeling are comparable to the interaction between cancer cells and connective tissue cells called stromal fibroblasts.
The invasion of fibroblasts into the airway in asthmatic patients is one of several key features of airway remodeling," Dr.
Accordingly, the present study suggests a potential involvement of PAF in airway remodeling due to its direct stimulation of ASMC proliferation, which broadens the role of PAF in the pathogenesis of COPD and provides a new theoretical basis for the special treatment of COPD targeting against PAF.
Thus our findings not only suggest the promosing action of NAC on the alleviation of airway remodeling in COPD but also provide a potentially theoretical basis for clinical administration of NAC at higher doses.
1], suggesting once more that the daily ICS does not have an effect on airway remodeling (N.
97), no change in hospitalizations or lung function, and no benefit on airway remodeling (N.
Additional presented data provide insight to IL-9's role in allergen-induced airway remodeling, a process involving structural changes that occur in conjunction with, or as a result of, chronic airway inflammation such as that seen in patients with asthma.
For example, one hypothesis is that recurrent inflammatory or allergic challenges to the airway leads to airway remodeling, a key feature in the development of irreversible airways obstruction in asthma and COPD.
1992), and in both of these groups, airway remodeling of this type appears to be associated with chronic airflow obstruction.
Asthma is a chronic disease characterized by acute airway constriction, chronic inflammation, and airway remodeling.
Regulation of Extracellular Matrix Components by Beta-Agonist Enantiomers: A Possible Role for Airway Remodeling.
In pre-clinical studies, CpG-based products have been shown to be long-lasting and have demonstrated the ability to help prevent airway remodeling associated with chronic symptoms, offering the potential to alter the effects of allergic disease.

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