agrin


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Agrin

A 150-kD extracellular matrix proteoglycan encoded by AGRN on chromosome 1p36.33, which plays a central role in the embryonic development of the neuromuscular junction, first identified in the synapse-rich electric organ of Torpedo californica which induces myotubular synaptic specialisation.

agrin

A protein released by motor neurons that brings about the close aggregation of acetylcholine receptors on muscle cells.
References in periodicals archive ?
A missing piece was how agrin and LRP4 get together.
The overall visual impression of such imagery is that these characters, these people, live in the grainy, pallid, continuous present, occasionally touched by a variegated glimpse of an even worse past (the lurid sexual assault of Agrin, in a quick flashback) or a potentially better future (the arrival of the American colors at the end).
Turetsky, Moberg, Mozley, Moelter, Agrin, Gur, et al.
New arrivals in the village include Henkov (Hirsh Feyssal), who has lost his arms and has premonitions, his sister Agrin (Avaz Latif) and her blind son.
Henkov also has a sister, Agrin (Avaz Latif) on whom Satellite has a crush.
But Satellite is also knocked for a loop by Hangao's sister Agrin (Avaz Latif), as lovely as she is suicidal.
The carboxy terminus of dystrophin binds to a plasma membrane anchor, [beta]-dystroglycan, which is associated on the external side with the extracellular matrix receptor, [alpha]-dystroglycan, which binds to the basal lamina proteins laminin 1, laminin 2, and agrin.
Similar gene therapy or drug treatment to increase natural agrin levels could offer new ways to treat MCMD in humans, the researchers concluded.
While researchers have shown that a protein called agrin controls the creation of similar synapses between nerve cells and muscles (SN: 5/25/96, p.
Yancopoulos and his team also identified agrin as the specific ligand for MuSK.
It targets the activation of MuSK (Muscle-Specific Kinase) by agrin, thus, disrupts AChRs clustering, one of the requirements for the ACh to trigger the contraction signal along the neuromuscular junction.