agranulocytosis /agran·u·lo·cy·to·sis/ (a-gran″u-lo-si-to´sis) a symptom complex characterized by decreased granulocytes and by lesions of the throat, other mucous membranes, gastrointestinal tract, and skin; most cases are complications of drug therapy, radiation, or exposure to chemicals.
Agranulocytosis
agranulocytosis
agranulocytosis (āgran´y
lōsītō´sis),
agranulocytosis
a·gran·u·lo·cy·to·sis ( -gr n y -l -s -t s s, -grn-)n. An acute disease characterized by high fever, lesions of the mucous membranes and skin, and a sharp drop in circulating granular white blood cells. |
Agranulocytosis
An acute condition marked by severe depression of the bone marrow, which produces white blood cells, and by prostration, chills, swollen neck, and sore throat sometimes with local ulceration. Aalso called agranulocytic angina or granulocytopenia.
Mentioned in: Antipsychotic Drugs, Central Nervous System Stimulants
agranulocytosis
[āgran′yoo͡lō′sītō′sis]
a severe reduction in the number of leukocytes (basophils, eosinophils, and neutrophils). Neutropenia results, whereby the body is severely depleted in its ability to defend itself. Fever, prostration, and bleeding ulcers of the rectum, mouth, and vagina may be present. The acute disease may be an adverse reaction to a medication or the result of the effect of radiation therapy or chemotherapy on bone marrow.
agranulocytosis (āgran´y
lōsītō´sis),n a decrease in the number of granulocytes in peripheral blood resulting from bone marrow depression by drugs and chemicals or replacement by a neoplasm. Oral lesions are ulceronecrotic, involving the gingivae, tongue, buccal mucosa, or lips. Regional lymphadenopathy and lymphadenitis are prevalent.
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Agranulocytosis.
agranulocytosis
a disease state characterized by a marked reduction in the granulocyte count in the blood and in the body's defenses against bacterial invasion. Called also granulocytopenia. See also feline panleukopenia.
agranulocytosis
Granulocytopenia, granulopenia Hematology A marked ↓ in PMNs < 500/mm3 Clinical Fever, malaise, mucocutaneous ulcers–throat, GI tract, skin Etiology Acquired due to adverse response to prescription
drugs–chloramphenicol, clozapine, nitrous oxide, procainamide, sulfonamides, thiazide diuretics. See Infantile genetic agranulocytosis.
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