agranulocytosis


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Related to agranulocytosis: neuroleptic malignant syndrome

agranulocytosis

 [a-gran″u-lo-si-to´sis]
an acute disease in which there is a dramatic decrease in the production of granulocytes, so that a pronounced neutropenia evolves, leaving the body defenseless against bacterial invasion. A great majority of cases are caused by sensitization to drugs or chemicals that affect the bone marrow and depress the formation of granulocytes. Called also malignant or pernicious leukopenia and idiopathic or malignant neutropenia.
Symptoms. The first manifestations are usually produced by a severe infection and include high fever, chills, prostration, and ulcerations of mucous membranes such as in the mouth, rectum, or vagina. Laboratory tests reveal a profound leukopenia (low leukocyte count).
Treatment. Treatment is aimed at immediate withdrawal of the drug or chemical causing the disorder, and control of infection. In most cases control can be achieved by the administration of antibiotics. If the bone marrow is not irreparably damaged, the prognosis is good with proper treatment, and the patient will recover as the production of granulocytes resumes. Occasionally the leukocyte-producing tissues are damaged beyond repair and death ensues.
infantile genetic agranulocytosis a severe congenital condition of virtual absence of neutrophils from the blood; most patients die of infection before reaching adulthood. Called also congenital neutropenia and Kostmann's syndrome or neutropenia.

a·gran·u·lo·cy·to·sis

(ă-gran'yū-lō-sī-tō'sis),
An acute potentially lethal condition characterized by pronounced leukopenia with great reduction in the number of polymorphonuclear leukocytes (frequently to fewer than 500 granulocytes/mm3); infected ulcers are likely to develop in the throat, intestinal tract, and other mucous membranes, as well as in the skin.

agranulocytosis

/agran·u·lo·cy·to·sis/ (a-gran″u-lo-si-to´sis) a symptom complex characterized by decreased granulocytes and by lesions of the throat, other mucous membranes, gastrointestinal tract, and skin; most cases are complications of drug therapy, radiation, or exposure to chemicals.

agranulocytosis

(ā-grăn′yə-lō-sī-tō′sĭs)
n.
An acute condition characterized by a marked decrease in circulating granulocytes, especially neutrophils, and often leading to infection. It is usually drug-induced or caused by exposure to radiation or toxic chemicals.

agranulocytosis

[āgran′yoo͡lō′sītō′sis]
severe reduction in the number of granulocytic leukocytes (basophils, eosinophils, and neutrophils). Reduction in polymorphonuclear neutrophils is neutrophilia, whereby the body is severely depleted in its ability to defend itself from bacterial infection. The acute disease may be an adverse reaction to a medication or the result of the effect of radiation therapy or chemotherapy on bone marrow

Agranulocytosis

A marked decrease in neutrophils < 500/mm3; it is loosely equivalent to neutropaenia in the working parlance.
Artiology Acquired due to prescription drugs—chloramphenicol, clozapine, nitrous oxide, procainamide, sulfonamides, thiazide diuretics.
Clinical findings Fever, malaise, mucocutaneous ulcers (throat, GI tract, skin).

agranulocytosis

Granulocytopenia, granulopenia Hematology A marked ↓ in PMNs < 500/mm3 Clinical Fever, malaise, mucocutaneous ulcers–throat, GI tract, skin Etiology Acquired due to adverse response to prescription drugs–chloramphenicol, clozapine, nitrous oxide, procainamide, sulfonamides, thiazide diuretics. See Infantile genetic agranulocytosis.

a·gran·u·lo·cy·to·sis

(ā'gran'yŭ-lō-sī-tō'sis)
An acute condition characterized by pronounced leukopenia; infected ulcers are likely to develop in the throat, intestinal tract, and other mucous membranes, as well as in the skin. Condition is an immunocompromised state.

agranulocytosis

A condition in which the white cells of the blood are not being produced in adequate quantity by the bone marrow. This is most commonly caused as a toxic side effect on the bone marrow of various drugs such as the sulphonamides, the thiouracil derivatives, PENICILLIN, CHLORPROMAZINE, CHLORPROPAMIDE, PHENINDIONE,AMIDOPYRINE and CHLOROTHIAZIDE. Because of the deficiency or absence of protective white cells, there is severe sore throat, fever, TOXAEMIA and sometimes SEPTICAEMIA. The condition may be fatal.

Agranulocytosis

An acute condition marked by severe depression of the bone marrow, which produces white blood cells, and by prostration, chills, swollen neck, and sore throat sometimes with local ulceration. Aalso called agranulocytic angina or granulocytopenia.

agranulocytosis

pronounced leukopenia (especially circulating polymorpho- nuclear leukocytes), e.g. due to chemotherapy or radiotherapy

a·gran·u·lo·cy·to·sis

(ā'gran'yŭ-lō-sī-tō'sis)
An acute potentially lethal condition characterized by pronounced leukopenia with great reduction in the number of polymorphonuclear leukocytes; infected ulcers are likely to develop in the throat, intestinal tract, and other mucous membranes, as well as in the skin; increases patients' risk of infection.

agranulocytosis (āgran´yŏŏlōsītō´sis),

n a decrease in the number of granulocytes in peripheral blood resulting from bone marrow depression by drugs and chemicals or replacement by a neoplasm. Oral lesions are ulceronecrotic, involving the gingivae, tongue, buccal mucosa, or lips. Regional lymphadenopathy and lymphadenitis are prevalent.
Enlarge picture
Agranulocytosis.

agranulocytosis

a disease state characterized by a marked reduction in the granulocyte count in the blood and in the body's defenses against bacterial invasion. Called also granulocytopenia. See also feline panleukopenia.
References in periodicals archive ?
Versacloz because of the risk of agranulocytosis with clozapine therapy will be available only through a restricted program called the Versacloz Patient Registry, which make sure suitable monitoring of white blood cell and absolute neutrophil count prior to delivery of the next refill of medication.
Because of the risk of agranulocytosis with clozapine therapy, Versacloz will be available only through a restricted program called the Versacloz Patient Registry, which ensures appropriate monitoring of white blood cell and absolute neutrophil count prior to delivery of the next refill of medication.
In 1975, clozapine entered Finland and following reports about clozapine-induced agranulocytosis and related mortality and morbidity in Finland and other countries, it was collected from the market [4].
SAMH-SA said there have been 20 confirmed or probable cases of agranulocytosis, including 2 deaths, in people who had ingested cocaine that was mixed with the antipara-site agent, which can suppress white blood cell counts.
A report from the International Agranulocytosis and Aplastic Anemia Study.
This toxicity and, specifically, the development of agranulocytosis remain a topic of discussion within the medical literature.
Adverse effects include sedation and a small risk of liver toxicity, aplastic anemia, and agranulocytosis.
Events reported with combination products included gynecomastia, postmenopausal bleeding, psychiatric disturbances, and agranulocytosis.
Because clozapine may produce agranulocytosis, which seriously affects the body's immune system, the patient receiving the drug must undergo regular laboratory blood testing.
patients treated experimentally at several hospitals, suggests that about 1 percent of those given the drug will develop agranulocytosis, a reduction in certain types of white blood cells critical in flighting infection.