Agouti-related protein | definition of agouti-related protein by Medical dictionary
Also found in: Acronyms
agouti-related protein (AGRP),
a protein that plays a role in maintaining body weight by inducing food intake; its nucleotide sequence or gene resides on chromosome 16 and has polymorphisms that potentially seem related to anorexia.
Agouti-Related Peptide A peptide produced in the arcuate nucleus in the hypothalamus, which increases appetite (an action countered by leptin), but reduces the rate of metabolism and energy expenditure. It is increased in obese subjects.
References in periodicals archive
4) Centrally Acting Drugs 4a) Compounds Predominantly Modulating Local Availability of Dopamine, Norepinephrine and Serotonin in the Brain 4b) MC4R (Melanocortin 4 Receptor) Agonists and MCH-R1 (Melanin-Concentrating Hormone Receptor 1) Antagonists 4c) H3 Receptor Antagonists 4d) Neuropeptide Y (NPY) Receptor Antagonists & Agouti-Related Protein
HMS is composed of two different populations of neurons, one set that expresses neuropeptides Y (NPY) and agouti-related protein
(AgRP) and a second set that expresses proopiomelanocortin (POMC), a precursor containing a-melanocyte-stimulating hormone (Richards et al.
The newly identified protein, agouti-related protein
(AGRP), may be an ideal target for such an approach, he said.