The modest reduction of long-chain acyl-CoAs within the arcuate nucleus (ARC) would increase the expression of both agouti-related peptide
(AgRP) and neuropeptide Y (NPY) and enhance feed intake (Obici et al.
Washington, Feb 9 ( ANI ): There are two vital cell types in the brain that are essential for the regulation of feeding behaviours - agouti-related peptide
(AgRP)-expressing neurons and proopiomelancortin (POMC)-expressing neurons.
The importance of ghrelin as a "hunger hormone" with orexigenic effects mediated by the hypothalamic peptides, agouti-related peptide
, and neuropeptide Y, and the fact that it is the most potent peripheral signal of diminishing energy stores, implies that ghrelin release might be the most important of the many redundant mechanisms ensuring human survival in times of famine (4).
Within the ARC, scientists have also identified two types of leptin-responsive neurons: the Agouti-related peptide
(AgRP) neurons, which stimulate appetite and the pro-opiomelanocortin (POMC) neurons, which curb appetite.
Coordinate regulation of neuropeptide Y and agouti-related peptide
gene expression by estrogen depends on the ratio of estrogen receptor (ER) a to ERa in clonal hypothalamic neurons.