agouti-related peptide


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agouti-related peptide (AgRP),

a peptide released with neuropeptide Y from specific neurons of the arcuate nucleus. These neurons are stimulated by ghrelin and inhibited by neuropeptide PYY and leptin. Release of agouti-related peptide and neuropeptide Y stimulates appetite while reducing metabolism.
See also: ghrelin, leptin, neuropeptide Y.

Agouti-Related Peptide

A peptide produced in the arcuate nucleus in the hypothalamus, which increases appetite (an action countered by leptin), but reduces the rate of metabolism and energy expenditure. It is increased in obese subjects.
References in periodicals archive ?
The modest reduction of long-chain acyl-CoAs within the arcuate nucleus (ARC) would increase the expression of both agouti-related peptide (AgRP) and neuropeptide Y (NPY) and enhance feed intake (Obici et al.
Washington, Feb 9 ( ANI ): There are two vital cell types in the brain that are essential for the regulation of feeding behaviours - agouti-related peptide (AgRP)-expressing neurons and proopiomelancortin (POMC)-expressing neurons.
The importance of ghrelin as a "hunger hormone" with orexigenic effects mediated by the hypothalamic peptides, agouti-related peptide, and neuropeptide Y, and the fact that it is the most potent peripheral signal of diminishing energy stores, implies that ghrelin release might be the most important of the many redundant mechanisms ensuring human survival in times of famine (4).
Within the ARC, scientists have also identified two types of leptin-responsive neurons: the Agouti-related peptide (AgRP) neurons, which stimulate appetite and the pro-opiomelanocortin (POMC) neurons, which curb appetite.
Coordinate regulation of neuropeptide Y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) a to ERa in clonal hypothalamic neurons.