Agonistic antibody | definition of agonistic antibody by Medical dictionary
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An antibody that stimulates or activates an organ. E.g., agonistic antibodies against the thyrotropin receptor in Grave disease stimulate the thyroid gland to release thyroid hormones that produce hyperthyroidism.
References in periodicals archive
The agonistic antibody
binds to and stimulates CD137 resulting in the strengthening of the otherwise weak immune response to tumors.
HGS-TR2J is an agonistic antibody
to TRAIL Receptor 2, and may offer certain therapeutic advantages in comparison to native TRAIL, due to its significantly longer circulating half-life and its exclusive specificity to TRAIL receptor 2.
1, 2) TRAIL-R2 mAb mimics the activity of native TRAIL and is therefore considered an agonistic antibody