aggrecanase


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aggrecanase

(ag-gre'ka-nāz),
An enzyme found in cartilage that degrades extracellular matrix, especially cartilage.
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References in periodicals archive ?
ADAMTS1, -4, -5, -8, -9 and -15 have aggrecanase activity whereas other members do not.
22) When used at dosages below 10 nmol/L, it causes an increased matrix synthesis while preventing matrix breakdown by inhibiting aggrecanase activity and harmful effects of nitric oxide and interleukin-1 (IL-1) on cartilage tissue.
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.
5) The inhibition of aggrecanase response was reported to be a consequence of metabolic changes that followed a marked increase in the intracellular glucosamine concentration, the exact mechanisms not yet being fully elucidated.
Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro.
They discovered that these agents decreased interleukin-1-induced gene expression of several matrix metalloproteinases and aggrecanases involved in cartilage breakdown.
These include not only the production of metalloproteinases, collagenases, and aggrecanases that lead to cartilage breakdown in chondrocytes, but also the production of cytokines, such as interleukin-1 (IL-1), tumor necrosis factor (TNF), IL-6, IL-8, and nitric oxide (NO).