18,40) The destructive effect of ADAMTS12 on aggrecan
has been also detected.
They also showed that glucosamine attenuated the decrease of aggrecan
and prevented the apoptosis of the NPC induced by IL-1J3.
Glucosamine also inhibited the aggrecan
degradation in a rat chondrosarcoma cell line and bovine cartilage explants, a result that was mediated by aggrecanase, a proteinase induced by interleukin-1 or retinoic acid.
IBEX expects to follow the release of new fetal aggrecan
assay with the release later this year of two additional next-generation arthritis assays, CPII and C2C, for use by the pharmaceutical community.
Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan
The density of aggrecan
molecules is decreased with a resultant increase in cartilage water content.
7) In trigger finger tendons, collagen type 1A1 and 3A1, aggrecan
, and biglycan are up-regulated, while metalloproteinase inhibitor 3 (TIMP-3) and matrix metallopeptidase (3) (MMP-3) are down-regulated, a situation also described in Achilles tendinosis.
20) The most abundant PG in articular cartilage and the ECM is aggrecan
which is composed of a core protein, hyaluronan (HA), and several side chains of GAGs.
The device will also force the differentiation of fibroblast cells in chondrocyte or chondrocyte-like cells for the production of aggrecan
, Type II collagen, Sox-9 protein cartilage link protein, and perlecan.
2005a,b) have shown that sclerotic osteoblasts inhibit aggrecan
production on protein and gene expression level and lead to a reduction in chondrogenic transcription factor SOX9 and collagen II on mRNA level compared to non-sclerotic osteoblasts.
The sequences of primers used in real-time PCR analyses were as follows: Aggrecan
forward GAGACCAAGTCCTCAAGCCC; reverse CTCTGTCTCCTGGCAGGTTC.
Damage to collagen fibers due to mechanical or inflammatory processes leads to aggrecan
decomposition, causing fiber oversaturation with water and mechanical loading-induced degeneration.