PRKCA

(redirected from ageing-associated gene 6)

PRKCA

A gene on chromosome 17q22-q23.2 that encodes a calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase, which up- or downregulates cell proliferation, apoptosis, differentiation, migration and adhesion; tumourigenesis; cardiac hypertrophy; angiogenesis; and platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signalling cascades involving MAPK1/3 and RAP1GA.