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A condition in which there are large whitish-yellow soft drusen in the macular area and hyperpigmentation or depigmentation of the retinal pigment epithelium associated with the drusen. Small hard drusen may also be present. It occurs most commonly in individuals over 50 years of age and represents the early stage of age-related macular degeneration. The risk of progression of this condition may be decreased by dietary supplements of vitamin C and E, antioxidants (carotenoids such as lutein and zeaxanthin) and minerals (zinc and cupric acid).