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aganglionosis

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aganglionosis /agan·gli·on·o·sis/ (a-gang″gle-on-o´sis) congenital absence of parasympathetic ganglion cells.
a·gan·gli·o·no·sis (-gnggl--nss)
n.
1. Absence of ganglion cells.
2. Congenital absence of the myenteric plexus ganglion cells.

aganglionosis
[əgang′lē·ənō′sis]
Etymology: Gk, a, not, gagglion, knot, osis, condition
an absence of parasympathetic ganglion cells in the myenteric plexus, a diagnostic sign of congenital megacolon.

aganglionosis [ah-gang″gle-on-o´sis]
congenital absence of parasympathetic ganglion cells, such as in congenital megacolon.

aganglionosis, agangliosis
congenital absence of parasympathetic ganglion cells.

colonic aganglionosis
congenital defect manifested by stenosis, but patency, of the colon, an absence of ganglia of the myenteric plexus and an almost complete absence of skin pigment in white foals resulting from matings between overo horses. The foal develops colic at birth and dies after about 48 hours. See also atresia. Occurs also in some spotted mutant strains of mice. Called also congenital megacolon, aganglionic megacolon.


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Three-dimensional morphology of gut innervation in total intestinal aganglionosis using whole-mount preparation.
MATERIALS AND METHODS Resected specimens of colon were obtained at the time of pull-through operation from 12 patients with HD, aged 21 days to 7 years; 10 patients had classic rectosigmoid HD, and 2 patients had total aganglionosis of the colon.
 
 
 
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