group, 29 (81%) out of 55 were male and 7 (19%) were female (M:F= 4.
sup] studied the bacteria of aganglionic
colon in Ednrb−/− mice.
The pathognomonic finding of Hirschsprung disease on contrast enema is a transition zone between the normal and aganglionic
bowel, although approximately 10% of neonates with Hirschsprung disease may not have a demonstrable radiologic transition zone.
There is no problem in pediatric patients with Hirschsprung that aganglionic
segment is located in colonic flexure while, the elderly patients may have limitations in this situation.
Moreover, laparoscopic assisted pullthrough for the definitive treatment is known to be associated with faster recovery period and fewer perioperative complications, as it reduces the adhesion formation and offers the possibility of a better mobilization and dissection of the aganglionic
colon [11, 12].
Archibong AE: Pattern of aganglionic
megacolon in Calabar, Nigeria.
Sustained contraction of the aganglionic
bowel is the main pathophysiologic feature of this disease, resulting in functional bowel obstruction in the newborn.
Type IV (Shah-Waardenburg syndrome) is associated with congenital aganglionic
megacolon (hirschprung disease).
Absence of NADPH-diaphorase activity has been reported in the aganglionic
colon in patients with Hirschsprung disease, and absent or reduced NADPH-diaphorase activity was reported in the nerves within the hypertrophied circular muscle in patients with pyloric stenosis.
She was then referred to a surgeon for resection of the aganglionic
This bacterial infection resulted in septicemia secondary to the Hirschprung's disease also known as Congenital Aganglionic
Megacolon causing functional colonic obstruction resulting in severe constipation and abdominal distension.
Hirschsprung disease (HD) is a disorder of intestinal innervation in which the 2 principal histologic features are the absence of ganglion cells and the presence of increased numbers of hypertrophic nerve bundles in the aganglionic
segment of bowel.