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afterload |
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afterload /af·ter·load/ (-lōd″) the force against which cardiac muscle shortens: in isolated muscle, the force resisting shortening after the muscle is stimulated to contract; in the intact heart, the pressure against which the ventricle ejects blood.
afterload Etymology: AS, aefter + ME lod the load, or resistance, against which the left ventricle must eject its volume of blood during contraction. The resistance is produced by the volume of blood already in the vascular system and by the constriction of the vessel walls. afterload see cardiac afterload. afterload Cardiology The amount of hemodynamic pressure–peripheral vascular resistance downstream from the heart–which ↑ in heart failure 2º to aortic stenosis and HTN. Cf Preload Physiology The tension produced by heart
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One
explanation for this paradox may be that an acute baroreceptor reflex is
occurring in response to an increased cardiac afterload. The additional right-side afterload and the relative inability
of the right ventricle to cope with chronic volume and pressure loading
can also lead to catastrophic failure of the right heart if left
untreated. [79]
Dobutamine also reduces cardiac afterload by blocking the effects of
catecholamines on vascular alpha-1 receptors. |
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