References in periodicals archive ?
The mechanism for hypotension and shock in sepsis are: reduced pre-load, myocardial suppression as well as reduced after-load contributing to hyperdynamic but insufficient cardiac function resulting in tachycardia and hypotension.
Compared to the inotrope dobutamine , CXL-1020 significantly reduced after-load, stroke work and energetic demand, demonstrating its unique, energetically favorable profile.
A useful way of describing the problem is to consider the patient's journey, using the analogy of the cardiac cycle and the concepts of pre-load, contractility and after-load.
Clinician can use this new technology to more rapidly assess the effects of treatment on cardiac function, for example, after-load reduction, or as a means to quantify valvular regurgitation.