aflatoxin B1-DNA adduct

aflatoxin B1-DNA adduct

A molecular complex (adduct) formed by aflatoxin B1 attaching to DNA, which occurs in humans exposed to aflatoxins in mouldy peanuts or corn. ABDAs can be identified in the urine and liver by fluorescent microscopy, and are markers of aflatoxin exposure and indicate an increased risk for liver cancer (hepatocellular carcinoma).
References in periodicals archive ?
By modulating cytochrome P450 function, curcumin reduces the aflatoxin B1-DNA adduct formation, thereby showing its potential to inhibit chemical carcinogenesis [9].
XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency.