Aequorin | definition of aequorin by Medical dictionary
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A luminescent protein isolated from the jellyfish Aequorea
that emits blue light in the presence of even minute amounts of calcium ion; injected intracellularly, it is used to measure free calcium ion transients within cells.
See also: fura-2
aequorin (ē-kwôr′ĭn, ē-kwŏr′-)
A protein secreted by certain bioluminescent jellyfish, used as a reagent in molecular biology to detect calcium concentrations inside cells.
A luminescent protein isolated from the jellyfish Aequorea, which emits blue light in the presence of even minute amounts of calcium ion; injected intracellularly, it is used to measure free calcium ion transients within cells.
See also: fura-2
References in periodicals archive
A part of aequorin
called coelenterazine reacts with oxygen to produce coelenteramide and carbon dioxide, while emitting light.
This discovery led to the use of aequorin
as an important biomedical tool for tracking the movement of calcium within cells.
The bioluminescent jellyfish Aequorea emits 'green' light in vivo, whereas the pure photoprotein aequorin
extracted from the same organism emits 'blue' light on addition of [Ca.
The observations may also be relevant in explaining the efficient energy transfer between aequorin
and GFP in the light-emitting organ of the jellyfish itself.
The output of this model (mentioned above) evokes a calcium signal detectable with high sensitivity aequorin
2+]-sensitive photoproteins such as aequorin
, found in the jellyfish Aequorea aequorea (Shimomura et al.
preparations (18) were generously provided by Dr.