adverse reaction


Also found in: Acronyms.

ad·verse re·ac·tion

any undesirable or unwanted consequence of a preventive, diagnostic, or therapeutic procedure or regimen.

adverse reaction

any harmful, unintended effect of a medication, diagnostic test, or therapeutic intervention.

Adverse Effect

Malpractice An injury caused by medical management—rather than by the underlying disease—which prolongs hospitalization, produces a disability at the time of discharge, or both.
Aetiology Drug effects, wound infections, technical complications, negligence, diagnostic or therapeutic mishaps, and events occurring in A&E.
Therapeutics An undesirable and unintended, although not necessarily unexpected, result of therapy or other intervention—e.g., headache following spinal tap or intestinal bleeding associated with aspirin therapy.
Toxicology An abnormal or harmful effect on an organism due to exposure to a chemical or noxious substance. Adverse events cause functional or anatomic damage, irreversible changes in homeostasis, or increased susceptibility to other chemical or biologic stress.
Clinical findings Change in food or liquid consumption, body or organ weight, enzyme activity, visible illness or death. Nonadverse effects usually fade when the organism is distanced from the toxin.
Trial Any undesirable symptom, occurrence or effect which a trial subject experiences during the trial, which may or may not be related to the study agent or intervention.
Examples Unfavourable and unintended reactions or findings—e.g., abnormal lab results, symptoms, or disease temporally associated with the use of a medicinal (investigational) product, whether or not it actually is related to the product.

The term adverse effect is often used interchangeably with adverse reaction, which might be better reserved for clinical phenomena occurring during drug treatment when causality cannot be or is not ascertained.

ad·verse re·ac·tion

(ad-vĕrs' rē-ak'shŭn)
Any undesirable or unwanted consequence of a preventive, diagnostic, or therapeutic procedure or regimen.

adverse reaction,

n a harmful, unintended effect of a medication, diagnostic test, or therapeutic intervention.
References in periodicals archive ?
Dr Martyn Carey, a consultant pathologist at the Queen Elizabeth Hospital, said Mrs West had also died from an adverse reaction to some kind of agent which may have been a drug.
A perspective on popular perceptions of adverse reactions to foods.
Intermittent users were Zomax's largest market, about 75 percent; any adverse reactions among this group of casual users would unquestionably slow sales.
The most common Grade 3 or 4 non-hematological adverse reactions (greater than or equal to 5%) were: pneumonia (7%), abdominal pain (5%), atrial fibrillation, diarrhea (5%), fatigue (5%), and skin infections (5%).
Fetal harm can occur when Gleevec is administered to a pregnant woman; therefore, women of childbearing potential should be advised to not become pregnant while taking Gleevec tablets and to avoid breast-feeding while taking Gleevec tablets because of the potential for serious adverse reactions in nursing infants.
Nearly all reported adverse reactions have occurred in three specific areas of product use -- hemodialysis, invasive cardiovascular procedures and apheresis procedures.
46 Proportion of adults who have ever taken a prescription medication and have ever had an adverse reaction to a prescribed medication.
The complaint by the commission also charges that Eli Lilly instructed its clinical trials investigators not to include symptoms of depression when reporting adverse reactions to the drug, citing that this is what the drug is prescribed for.
The adverse reaction involved one confirmed case in Florida in which a beekeeper observed disorientation and a noticeable increase in the mortality rate in his bees about a week after Miticur had been applied to the hives.
In the trials, a decrease in certain infection- fighting white blood cells was the only serious adverse reaction that occurred in more patients who received rifabutin than patients who received a placebo.
The overall adverse reaction rate was 62 per 10,000 persons vaccinated, and reactions were generally mild to moderate, including hives, itching and wheezing.