advanced glycation endproducts


Also found in: Acronyms.

advanced glycation endproducts

; AGEs formation of endproducts of non-enzymatic protein lipoproteins and nucleic acid glycosylation; exaggerated in old age, but accelerated in poorly controlled diabetes mellitus; AGEs accumulate in structural proteins (of ligaments, blood vessel walls, etc.) to compromise the microcirculation, especially within skin, vasa vasorum and vasa nervosum, contributing to the secondary complications of long-term diabetes, i.e. loss of joint mobility, neuropathy and ischaemia (see glycosylated haemoglobin; glycosylation)
References in periodicals archive ?
Advanced glycation endproduct crosslinking in the cardiovascular system: potential therapeutic target for cardiovascular disease.
It has been demonstrated that administration of the renal advanced glycation endproducts inhibitor aminoguanidine ameliorated the diabetes induced nephrin protein depletion (Dempsey et al.
Receptor for advanced glycation endproducts and atherosclerosis: from basic mechanisms to clinical implications.
Roles of the receptor for advanced glycation endproducts in diabetes-induced vascular injury.
Ono Y, Aoki S, Ohnishi K, Yasuda T, Kawano K, Tsukada Y (1998) Increased serum levels of advanced glycation endproducts and diabetic complications.
Epinex Diagnostics, a private biomedical company, specializes in the development of innovative rapid tests that target major deficiencies in the existing healthcare market, including diabetes monitoring and diagnosis, rheumatoid arthritis, advanced glycation endproducts, and Down syndrome.
Several recent publications, however, have raised the question of whether d-ribose--because it is a sugar--could possibly contribute to development of harmful advanced glycation endproducts.
They include ammonia, indoles (serotonin, octopamine), histamine, secondary bile acids, advanced glycation endproducts (AGE), and certain bacterial toxins.
The lysine is exceptionally prone to glycation (2) and to modification by advanced glycation endproducts.
Some sugar, of course, is inevitably absorbed, and is responsible for formation of the dangerous carbonyl molecules that react with proteins and DNA to form advanced glycation endproducts, or AGEs.

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