Oxytocin increases locus coerruleus alpha 2 adrenoreceptor
responsiveness in rats.
2) The action of one drug is prevented by a second drug acting on a separate part of the signalling pathway, eg verapamil prevents entry of calcium into myocardial cells and will counter the effects of dobutamine (a beta-1 adrenoreceptor
In humans, the mechanism of the latter was suggested to be the result of alpha-2 adrenoreceptor
proliferation at the site of nerve damage and reduced transmission of nociceptive impulses and prevention or lessening of spinal cord sensitization when these receptors are activated.
The effects of the adrenoreceptor
agonist phenylephrine and isoproterenol on the intracellular ion concentration of branchial ephitelial cells of brown trout (Salmo trutta L).
As highlighted below, delivering targeted ingredients directly into the skin has one key objective: to initiate lipolysis using a strategy that does not depend on beta-adrenoreceptor
activation, since subcutaneous fat cells have a lower concentration of beta adrenoreceptors
(which stimulate lipolysis) and a higher concentration of alpha adrenoreceptors
(which inhibit lipolysis).
That observation, adds Bond, was an indication that blocking the receptor, scientifically known as beta-2 adrenoreceptor
, might be a safer and more effective strategy for long-term asthma management than stimulating it.
Other hypothetical mechanisms could be ECG changes (such as QT-fnterval prolongation), pro coagulation effects, or direct effects on blood pressure via adrenoreceptor
antagonism," the investigators noted.
Since we did not measure serum cortisol levels or the pituitary-adrenal axis function, we are unable to determine whether this had a significant role in altering adrenoreceptor
The Foradil Aerolizer (formoterol inhalation powder), a long-acting, selective [beta]-2 adrenoreceptor
agonist manufactured by Novartis Pharmaceuticals Corp.
Ephedrine is a direct agonist and an indirect adrenoreceptor
agonist, causing release of noradrenaline from presynaptic sympathetic nerve terminals.
In this model, cardiotoxicity does not only occur via adrenoreceptor
activation (22), but also ISO induces excessive production of free radicals resulting from oxidative metabolism of catecholamines and thus, the free radicals cause cell necrosis and contractile failure in the heart (23).
Pfizer will remain the market leader with its current blockbuster therapy, donepezil (Aricept), and the launch of its upcoming alpha adrenoreceptor
antagonist, nicergoline (Sermion), expected to reach Europe and the U.