adrenomedullin


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adrenomedullin

A peptide produced by vascular endothelium and the adrenal medulla; in experimental animal studies, it exerts a long-lasting hypotensive effect associated with reduced vascular resistance and inhibition of aldosterone secretion from the zona glomerulosa of the adrenal cortex.
[adreno- + medulla + -in]

Adrenomedullin

Either of two (AM1, AM2) widely expressed peptides encoded by ADM on chromosome 11p15.4, which is thought to function as a hormone in the peripheral circulation.
Physiologic functions AM (AM2 is less well studied) is a potent vasodilator and involved in a broad range of physiologic activities including control of fluid and electrolyte homeostasis. In the kidney, it is diuretic and natriuretic, and inhibits aldosterone secretion by direct antagonism. AM inhibits basal ACTH secretion in the pituitary and brain, where it facilitates loss of plasma volume, thus complementing its hypotensive effect on peripheral vessels. It is involved in angiogenesis and increases cell tolerance of oxidative stress and hypoxic injury.
Angiogenesis AM has a positive impact on hypertension, myocardial infarction, and COPD.
Cognate receptors Calcitonin receptor like receptor (CALCRL), receptor activity-modifying proteins (RAMP2), and complexes, as well as calcitonin gene related peptide (CGRP) receptor.

adrenomedullin

(ă-drē″nō-mĕ-dŭl′ĭn) [ adreno- + medullin, a renal prostaglandin],

AM

A 52–amino acid regulatory peptide that influences many body functions. These functions include blood vessel dilation (lowering blood pressure), cellular growth, circulation, electrolyte balance, kidney function, and neurotransmission. The level of adrenomedullin in the blood is elevated above normal in patients with congestive heart failure, kidney failure, and diabetes mellitus complicated by vascular disease.
References in periodicals archive ?
Chronic administration of adrenomedullin attenuates hypoxic pulmonary vascular structural remodeling and inhibits proadrenomedullin Nterminal 20-peptide production in rats.
Distribution and characterization of immunoreactive adrenomedullin in human tissue and plasma.
The observed renoprotective effects of HIF activation may be linked to the induction of cytoprotective factors, including: heme oxygenase, which plays a role in the metabolism of excess heme that would otherwise cause oxidative injury; Glut-1, a critical glucose transporter that enables continued energy generation in hypoxic environments; and adrenomedullin, a potent vasodilating peptide that regulates cardiac and renal function.
Dogumdan sonra pulmoner vaskuler direncin azalmasini saglayan etkenler oksijenasyon, akciger distansiyonunu takiben kapillerlerin acilmasi, bradikinin, adrenomedullin, adenozin, prostasiklin ve nitrik oksit (NO) uzerinden olusan vazodilatasyon ve daha uzun surede vaskuler yeniden yapilanmadir (3).
Adrenomedullin, a strong peripheral vasodilator, and its counterpart endothelin, a powerful vasoconstrictor, both play a prominent role in cardiovascular disease, but reliable measurements of these constituents are hampered by their instability and binding to plasma proteins.
The paper, which is titled "Development of Radiolabeled Adrenomedullin Analogs Designed for Molecular Imaging of the Pulmonary Circulation", will be part of the session "From a Peptide to a Drug: Rational Drug Design".
Proadrenomedullin N-terminal 20 peptide (PAMP) is a peptide formed from preproadrenomedullin which is the precursor of adrenomedullin (1).
Adrenomedullin, endothelin, neuropeptide Y, atrial, brain, and C-natriuretic prohormone peptides compared as early heart failure indicators.
Plasma adrenomedullin (ADM) levels are elevated in various pathological states including cardiovascular and inflammatory diseases.
We investigated whether open heart surgery with CPB changes cerebrovascular resistance and adrenomedullin (AM) secretion, and whether AM measurement is useful for monitoring cerebral distress during CPB.