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ACTHA 39-amino acid hormone produced by the anterior pituitary gland, which regulates adrenocortical activity, stimulating release of cortisol, mineralocorticoids, and adrenal androgens; pituitary ACTH is regulated by corticotropin-releasing hormone (CRH).
Daily pattern ACTH levels vary over the space of a 24-hour day, peaking at 6–8 am and evening 6–11 pm; ACTH suppression or stimulation testing may be required to confirm the diagnosis of changes in adrenal function.
ACTH increased in Addison’s disease, congenital adrenal hyperplasia, Cushing disease, pituitary-dependent Cushing syndrome, ectopic ACTH-producing tumours, Nelson syndrome.
ACTH decreased in Secondary adrenocortical insufficiency, adrenal carcinoma, adenoma.
Ref range < 120 pg/mL
ad·re·no·cor·ti·co·tro·phic hor·mone(ă-drēnō-kōŕti-kō-trōfik hōŕmōn)
hormonechemical substance that acts locally or is carried via blood to another body part, to cause a regulatory effect on functional activity or structure
adrenocorticotrophic hormone; ACTH; corticotrophin; adrenocorticotrophin anterior pituitary hormone stimulating release of glucocorticoid and mineralocorticoid and sex hormones (androgens) from cortex of adrenal gland; plasma ACTH levels are reduced in Cushing's syndrome (due to excess production of adrenal cortex hormones) and raised in Addison's disease (due to reduced adrenal cortex function)
antidiuretic hormone; ADH; vasopressin anterior pituitary hormone; causes urine concentration by increasing resorption of solute at the distal convoluted tubule of nephron; absence of ADH causes diabetes insipidus
follicle-stimulating hormone; FSH anterior pituitary hormone; acts on ovaries/testes to influence the release of the sex hormones (oestrogen/testosterone), and induce sperm growth/ovulation
growth hormone; GH; somatotropin anterior pituitary hormone; acts on many tissues, inducing normal growth
luteinizing hormone; LH anterior pituitary hormone; acts on ovaries/testes to influence sex hormone release (oestrogen/testosterone) and induce sperm growth/ovulation