adrenocortical carcinoma


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adrenocortical carcinoma

Oncology A rare–≤ 2 in 106/yr tumor of the adrenal cortex; average age 46; ♂:♀ ratio 1:2.5 Clinical ± 70% of Pts with AC have endocrine symptoms due to excess secretion of glucocorticoids and/or androgens, less commonly due to excess mineralocorticoids or estrogens Management Surgical resection, mitotane. See Mitotane.
Adrenocortical cancer
Stage I
CA < 5 cms; no spread to periadrenal tissues
Stage II
CA > 5 cms; no spread to periadrenal tissues
Stage III
CA spread to periadrenal tissues or lymph nodes
Stage IV
CA spread to regional tissues or organs, to lymph nodes around adrenal cortex, or metastasized
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References in periodicals archive ?
Adrenocortical carcinoma in the United States: Treatment utilization and prognostic factors.
Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis.
Adrenocortical carcinomas (ACCs) are highly aggressive uncommon malignancies with a worldwide incidence of about 0.
Adrenocortical carcinomas account for 14% of all incidentalomas.
Identify and understand important and diverse types of therapeutics under development for Adrenocortical Carcinoma (Adrenal Cortex Cancer).
Adrenocortical carcinoma (ACC) is a rare, malignant tumor of the adrenal gland.
Pathologic features of prognostic significance in adrenocortical carcinoma," American Journal of Surgical Pathology, vol.
Renal cell carcinoma and adrenocortical carcinoma are usually readily diagnosed clinically and radiographically.
Among patients with adrenal masses Adrenocortical carcinoma (ACC) and malignant pheochromocytomas (MPH) are found with a low incidence but very unfavorable prognosis.
Although laparoscopic adrenalectomy represents the standard of care in managing adrenal masses, open surgery still has a major role in management of adrenal masses, suspected to be adrenocortical carcinoma (ACC).
The human adrenocortical carcinoma cell line H295R expresses all key enzymes involved in the synthesis of adrenocorticol steroid hormones from cholesterol and is being evaluated as a potential screening assay for EACs with effects on steroid biosynthesis.
Adrenocortical Carcinoma (Adrenal Cortex Cancer) - Pipeline Review, H1 2012', provides an overview of the Adrenocortical Carcinoma (Adrenal Cortex Cancer) therapeutic pipeline.