adrenoceptor

ad·re·ner·gic re·cep·tors

reactive components of effector tissues, most of which are innervated by adrenergic postganglionic fibers of the sympathetic nervous system. Such receptors can be activated by norepinephrine and/or epinephrine and by various adrenergic drugs; receptor activation results in a change in effector tissue function, such as contraction of arteriolar muscles or relaxation of bronchial muscles; adrenergic receptors are divided into α-receptors and β-receptors, on the basis of their response to various adrenergic activating and blocking agents.

adrenoceptor

/adre·no·cep·tor/ (ah-dre″no-sep´ter) adrenergic receptor.adrenocep´tive

Adrenergic Receptor

Any of a family of G protein-coupled cell membrane receptors which receive neuronal impulses from postganglionic adrenergic fibres of the sympathetic nervous system, which are divided into:
(1) Alpha receptors, which evoke an excitatory response of smooth muscle cells to catecholamines. Alpha receptors are divided into alpha1 (Gq) and alpha2 (Gi) coupled receptors.
Selective agonist, alpha receptor Phenylephrine
Alpha receptor effects Vasoconstriction, reduced GI tract motility.
(2) Beta receptors, which dampen the response to catecholamines. Beta receptors are divided into beta1, beta2, beta3, which are linked to Gs, and adenylate cyclase, increasing cAMP, which in turn drives cAMP-dependent protein kinase that mediates intracellular events.
Selective agonist, beta receptor Isoprenaline
Beta receptor effects Increased cardiac output, increased renin secretion from juxtaglomerular cells, increased gastric ghrelin secretion, smooth muscle relaxation resulting in bronchodilation, reduced GI motility, relaxation of detrusor muscle of the bladder, lipolysis, glycogenolysis and gluconeogenesis, increased renin secretion, insulin secretion, vasodilation, anabolism and thermogenesis of skeletal muscle.

adrenoceptor

See BETA-ADRENOCEPTOR.

ad·re·ner·gic re·cep·tors

(ad'rĕ-nĕr'jik rĕ-sep'tŏrz)
Reactive components of effector tissues, most of which are innervated by adrenergic postganglionic fibers of the sympathetic nervous system. Such receptors can be activated by norepinephrine and/or epinephrine and by various adrenergic drugs.
Synonym(s): adrenoceptor.

adrenoceptor

see adrenergic receptors.
References in periodicals archive ?
2]P adrenoceptor mediated vasoconstrictive effects, attenuation of inflammatory response, and direct action on peripheral nerve.
reviews for anti-muscarinic agents and beta-3 adrenoceptor agonist
DCM had multiple potential causes, but one team had found a strong association between HLA-DR4 positive DCM and having beta-1 adrenoceptor autoantibodies, "72% of the HLA-DR4 dilated cardiomyopathy patients had anti-beta-receptor antibodies compared to 22% HLA-DR4-negative patients; conversely, 67% of the antibody-positive patients were typed as HLA-DR4 compared to only 10% of the antibodynegative patients.
Liu, "Enhanced vasoconstriction to [alpha]1 adrenoceptor autoantibody in spontaneously hypertensive rats," Science China Life Sciences, vol.
Katoch, "Beta adrenoceptor agonists, clenbuterol, and isoproterenol retard denervation atrophy in rat gastrocnemius muscle: use of 3-methylhistidine as a marker of myofibrillar degeneration," Japanese Journal of Physiology, vol.
Dexmedetomidine, a highly selective alpha-2 adrenoceptor agonist with sedative and analgesic properties has been found to reduce the anesthetic requirements during general anesthesia.
Animal and laboratory studies have suggested that alpha-2 adrenoceptor agonists like clonidine might block stress-related drug-seeking behavior, independently of their action as adjunctive medications during opioid detoxification.
The company's product portfolio includes alpha adrenoceptor agonist, analgesic, antipyretic, anti-inflammatory, anti-ulcer agents, antibiotics and stimulants, among others.