adrenergic agonist

(redirected from adrenergic receptor agonist)
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adrenergic agonist

A family of agents which have adrenaline-like effects, acting directly or indirectly on any of the five G-protein-coupled adrenergic receptors: apha1, alpha2, beta1, beta2, beta3.

Actions of adrenergic agonists
alpha1 receptors: Activate phospholipase C (via Gq), increasing protein kinase C activity.
alpha2: receptors Inhibit adenylate cyclase (via G1), decreasing protein kinase A activity.
beta receptors: Activate adenylate cyclase (via Gs), increasing protein kinase A activity.

adrenergic agonist

Any of a group of therapeutic agents, e.g. epinephrine, that mimic or stimulate the sympathetic nervous system.
See also: agonist

sympathomimetic drugs 

Drugs that produce an effect similar to that obtained by stimulation of the sympathetic nervous system. Some of these predominantly act on the adrenergic alpha-receptors (e.g. noradrenaline (norepinephrine)), while others act on the adrenergic beta-receptors (e.g. isoproterenol). Others have little direct effect on the adrenergic receptors but enhance the release of natural catecholamine from the sympathetic nerve terminals (e.g. amphetamine, phenylpropanolamine). Sympathomimetic drugs are used (1) in the treatment of open-angle glaucoma by decreasing aqueous humour secretion and increase the outflow through the trabecular meshwork thus reducing the intraocular pressure (e.g. adrenaline (epinephrine), apraclonidine, dipivefrine hydrochloride, brimonidine tartrate), (2) dilate the pupil without affecting accommodation (e.g. phenylephrine) and (3) constrict conjunctival blood vessels (e.g. naphazoline, tetrahydrozoline). Syn. adrenergic agonist; adrenergic stimulating agent. See alpha-adrenergic agonist; mydriatic.

ad·re·ner·gic ag·o·nist

(adrĕ-nĕrjik agŏ-nist)
An agent capable of combining with receptors to initiate actions of or like epinephrine.
See: agonist
See also: epinephrine
References in periodicals archive ?
The extended-release form of the drug is a selective alpha-2A adrenergic receptor agonist and was first approved for the treatment of hypertension in 2002, and for ADHD in 2007.
Galderma portfolio expands to offer a fast onset and long-acting alpha-2 adrenergic receptor agonist -
5 percent and 10 percent is an alpha-1 adrenergic receptor agonist used for dilation of the pupil due to its vasoconstrictor and mydriatic action.
5% and 10% is an alpha-1 adrenergic receptor agonist used for dilation of the pupil due to its vasoconstrictor and mydriatic action.
The alpha-2 adrenergic receptor agonist guanfacine (Tenex) also seems, on the basis of clinical experience and limited research, to have some value for hyperactivity, Dr.
Preclinical Data on A2A and Beta-2 Adrenergic Receptor Agonist Programs in B-Cell Malignancies To Be Presented
to develop and market ADX415, a novel patented, centrally-acting alpha adrenergic receptor agonist, specific to Alpha-2 receptors, for the treatment of hypertension and other potential indications.
5%, an alpha adrenergic receptor agonist with a beta adrenergic receptor inhibitor, for the reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension who require adjunctive or replacement therapy due to inadequately controlled IOP.
2 Percentage of patients who receive the adrenergic receptor agonist drug clonidine for the treatment of Hypertension
In experiments carried out in heroin-(11) and cocaine-trained rats (12) and rats trained with a heroin-cocaine mixture (13), we found that pharmacological inhibition of NE cell firing and release (by systemic injections of alpha-2 adrenergic receptor agonists at doses that suppress NE cell firing through auto-inhibition), strongly attenuated footshock-induced relapse.

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