adrenergic agonist


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Related to adrenergic agonist: Adrenergic antagonist

adrenergic agonist

A family of agents which have adrenaline-like effects, acting directly or indirectly on any of the five G-protein-coupled adrenergic receptors: apha1, alpha2, beta1, beta2, beta3.

Actions of adrenergic agonists
alpha1 receptors: Activate phospholipase C (via Gq), increasing protein kinase C activity.
alpha2: receptors Inhibit adenylate cyclase (via G1), decreasing protein kinase A activity.
beta receptors: Activate adenylate cyclase (via Gs), increasing protein kinase A activity.

adrenergic agonist

Any of a group of therapeutic agents, e.g. epinephrine, that mimic or stimulate the sympathetic nervous system.
See also: agonist

sympathomimetic drugs 

Drugs that produce an effect similar to that obtained by stimulation of the sympathetic nervous system. Some of these predominantly act on the adrenergic alpha-receptors (e.g. noradrenaline (norepinephrine)), while others act on the adrenergic beta-receptors (e.g. isoproterenol). Others have little direct effect on the adrenergic receptors but enhance the release of natural catecholamine from the sympathetic nerve terminals (e.g. amphetamine, phenylpropanolamine). Sympathomimetic drugs are used (1) in the treatment of open-angle glaucoma by decreasing aqueous humour secretion and increase the outflow through the trabecular meshwork thus reducing the intraocular pressure (e.g. adrenaline (epinephrine), apraclonidine, dipivefrine hydrochloride, brimonidine tartrate), (2) dilate the pupil without affecting accommodation (e.g. phenylephrine) and (3) constrict conjunctival blood vessels (e.g. naphazoline, tetrahydrozoline). Syn. adrenergic agonist; adrenergic stimulating agent. See alpha-adrenergic agonist; mydriatic.

ad·re·ner·gic ag·o·nist

(adrĕ-nĕrjik agŏ-nist)
An agent capable of combining with receptors to initiate actions of or like epinephrine.
See: agonist
See also: epinephrine
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The authors also offer recommendations for safe practice in obstetrics in light of the teratogenic risk posed by beta 2 adrenergic agonists.
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Historically, the first step in characterizing adrenergic agonists was to separate [alpha]-AR from [beta]-AR (Sillence et al.
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The alpha 2 adrenergic agonists clonidine and guanfacine were developed 30 years ago to treat hypertension, but have been used off-label to treat Tourette's syndrome, developmental disorders, substance abuse, and ADHD.
Determination of adrenergic agonists from extracts and herbal products of Citrus aurantium L.
The American Academy of Allergy and Immunology recommends that patients using beta-2 adrenergic agonists for relief of airflow obstruction in asthma should continue their use as recommended by their physician.
There are three classes of bronchodilators: anticholinergics, methylxanthines, and beta adrenergic agonists.
Five main classes of medical treatment are currently used to lower intraocular pressure: prostaglandins, beta blockers, alpha adrenergic agonists, carbonic anhydrase inhibitors, and fixed dose combinations.